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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Biochemical Evaluation of Patients with Acute Pancreatitis

Svetlana Ignjatović / Nada Majkić-Singh / Mihajlo Mitrović / Miomir Gvozdenović

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 11, Pages 1141–1144, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2000.173, June 2005

Publication History

Published Online:
2005-06-01

Abstract

In this study we determined the clinical accuracy of α2- macroglobulin, α-amylase, C-reactive protein, lipase, non-esterified fatty acids, pancreatic α-amylase and phospholipase A in the diagnosis and prognosis of acute pancreatitis in a group of patients with acute abdominal pain using receiver operator characteristic curve analysis. We investigated 59 patients with acute pancreatitis and 72 patients with extrapancreatic diseases of gastrointestinal origin. On the basis of initial enzyme activities, at cut-offs of 245 U/l for amylase, 656 U/l for lipase, and 182 U/l for pancreatic α-amylase, the diagnostic efficiencies were 0.993, 0.980, and 0.975, respectively. Receiver operator characteristic curve analysis showed the same diagnostic accuracies. We evaluated the accuracy of serum α2-macroglobulin, C-reactive protein, non-esterified fatty acids and phospholipase A for differentiation between acute necrotizing pancreatitis and acute oedematous pancreatitis. C-reactive protein had the highest prognostic accuracy of the parameters studied (the area under curve = 0.9082) and at a cut-off value of 126 mg/l, sensitivity and specificity were 0.759 and 0.912, respectively. The role of the clinical laboratory in the investigation of patients with acute pancreatitis continues to evolve and biochemical parameters are a good diagnostic and prognostic option.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Nada Majkic-Singh
Jugoslovenska medicinska biohemija, 2002, Volume 21, Number 3, Page 245
[2]
Keisuke Maeda, Masahiko Hirota, Atsushi Ichihara, Masaki Ohmuraya, Daisuke Hashimoto, Hiroki Sugita, Hiroshi Takamori, Keiichiro Kanemitsu, and Hideo Baba
Pancreas, 2006, Volume 32, Number 1, Page 87

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