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Publication Date:
June 2005
ISSN:
1437-4331
DOI:
10.1515/CCLM.2000.177

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Clinical Chemistry and Laboratory Medicine (CCLM)

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Stability of Cardiac Troponins and CK-MB Mass Isoenzyme

Alun Price / Christine Burgin / Martin Cruise

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 11, Pages 1159–1160, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2000.177, June 2005

Publication History:
Published Online:
2005-06-01

Abstract

The stability of an analyte can have an important influence on its diagnostic performance and therefore should be documented before an analyte is introduced into routine practice. The stability of creatine kinase MB isoenzyme (CK-MB), troponin I and troponin T was studied by incubating samples at temperatures between 26° C and 39° C for periods up to 5400 min. Arrhenius plots were made which showed that all three proteins demonstrated a rapid decrease in stability between 15° C and 20° C. The activation energies for CKMB, troponin I and troponin T were 7.7, 6.34 and 6.34 cal/mol, respectively.

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