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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year

IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310



Identifying Bacteria in Human Urine: Current Practice and the Potential for Rapid, Near-Patient Diagnosis by Sensing Volatile Organic Compounds

Nicolas Guernion / Norman M. Ratcliffe / Peter T.N. Spencer-Phillips / Robin A. Howe

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 10, Pages 893–906, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2001.146, June 2005

Publication History

Published Online:


Urinary tract infection (UTI) represents a significant burden for the National Health Service. Extensive research has been directed towards rapid detection of UTI in the last thirty years. A wide range of microbiological and chemical techniques are now available to identify and quantify bacteria in urine. However, there is a clear and present need for near, rapid, sensitive, reliable analytical methods, preferably with low-running costs, that could allow early detection of UTI and other diseases in urine. Here we review the “state of the art” of current practice for the detection of bacteria in urine and describe the advantages of the recent “e-nose” technology as a potential tool for rapid, near-patient diagnosis of UTI, by sensing volatile organic compounds (VOCs).

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