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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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IFCC Reference Measurement Procedure for Substance Concentration Determination of Total Carbon Dioxide in Blood, Plasma or Serum

Robert W. Burnett / Arthur K. Covington / Niels Fogh-Andersen / Wolf R. Külpmann / Andrzej Lewenstam / Anton H. J. Maas / Antonius L. VanKessel / Willem G. Zijlstra

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 3, Pages 283–289, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2001.39.3.283, July 2005

Publication History

Published Online:


A reference measurement procedure for substance concentration determination of total CO2 in blood, plasma (the anticoagulant is usually heparin) or serum is described. The document covers the principle of the method, the materials and equipment needed and essential aspects of the procedure. The substance concentration of total CO2 in blood, plasma or serum is accurately determined and therefore this procedure is recommended for assigning reference values to reference materials and for blood gas quality assurance in laboratories and by manufacturers of blood gas equipment.

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