Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

30,00 € / $42.00 / £23.00

Get Access to Full Text

Plant Sterol-Enriched Margarine Lowers Plasma LDL in Hyperlipidemic Subjects with low Cholesterol Intake: Effect of Fibrate Treatment

Fabienne Nigon / Catherine Serfaty-Lacrosnière / Isabel Beucler / Dominique Chauvois / Carol Neveu / Philippe Giral / M. John Chapman / Eric Bruckert

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 7, Pages 634–640, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2001.103, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Phytosterols, found in fat-soluble fractions of plants, chemically resemble cholesterol and inhibit cholesterol absorption in the small intestine. Phytosterol consumption in human subjects reduces plasma total and low density lipoprotein-cholesterol (LDL-C) levels. The primary aim of this study was to determine the efficacy of a low-fat spread enriched with plant sterols in reducing total and LDL-C concentrations in primary hypercholesterolemia. The secondary objective was to evaluate whether patients receiving a lipid-lowering drug (fibrate) might differ in their response to plant sterols. The study was a randomized, double-blind, placebo-controlled two-period cross-over trial with two treatments and three periods. Both treatment periods lasted 2 months, with a washout period (2 months) between them. Spread enriched with plant sterols was compared to non-enriched control spread. Fortified fat spread provided 1.6 g/day of plant sterols derived from edible vegetable oils and fatty acids from sunflower seed oil. The plant sterol content consisted of sitosterol esters (50%), campesterol esters (25%), stigmasterol esters (20%) and 10% of other esters. Data in 53 hypercholesterolemic patients (31 females and 22 males) who completed the study were as follows: patients were 58±12 years of age with mean body mass index 23.5±2.8 kg/m2 (mean±SD). No adverse side-effects of the diet were reported. Plasma total cholesterol and LDL-C concentrations were significantly reduced by 6.4% and 8.8%, respectively, after using the spread enriched in plant sterols, as compared to controls (0.0% and 1.3%, respectively). No effect on high density lipoprotein-cholesterol (HDL-C) and lipoprotein(a) concentrations was detected. When subjects were divided in two subgroups according to fibrate treatment, supplementation with phytosterols decreased plasma cholesterol and LDL-C by 8.5% and 11.1%, respectively in the subgroup of patients treated with fibrates. In the group of patients who did not receive fibrates, consumption of plant sterol margarine reduced plasma cholesterol and LDL-C by 5.5% and 7.7%, respectively. Spread enriched with plant sterol esters significantly lowers blood total and LDL-C levels without affecting HDL-C concentrations, in a hypercholesterolemic population following a strict low cholesterol diet (NCEP step1). In addition, a combination of fibrate treatment and plant sterol ester-supplemented spread offers a safe and effective measure to significantly decrease abnormally high cholesterol levels. We conclude that phytosterol-enriched spread is a useful adjunctive therapy for hypercholesterolemic patients.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Tatu Miettinen and Helena Gylling
Annals of Medicine, 2004, Volume 36, Number 2, Page 126
[2]
Jordi Merino, Luis Masana, Carlos Guijarro, Juan Ascaso, Manuel Lagares, and Fernando Civeira
Clínica e Investigación en Arteriosclerosis, 2014, Volume 26, Number 3, Page 147
[3]
Helena Gylling, Jogchum Plat, Stephen Turley, Henry N. Ginsberg, Lars Ellegård, Wendy Jessup, Peter J. Jones, Dieter Lütjohann, Winfried Maerz, Luis Masana, Günther Silbernagel, Bart Staels, Jan Borén, Alberico L. Catapano, Guy De Backer, John Deanfield, Olivier S. Descamps, Petri T. Kovanen, Gabriele Riccardi, Lale Tokgözoglu, and M. John Chapman
Atherosclerosis, 2014, Volume 232, Number 2, Page 346
[4]
Mandana Amir Shaghaghi, Suhad S. Abumweis, and Peter J.H. Jones
Journal of the Academy of Nutrition and Dietetics, 2013, Volume 113, Number 11, Page 1494
[5]
É. Bruckert and R. Rodi Courie
EMC - Endocrinologie - Nutrition, 2011, Volume 8, Number 1, Page 1
[6]
Martijn B. Katan, Scott M. Grundy, Peter Jones, Malcolm Law, Tatu Miettinen, and Rodolfo Paoletti
Mayo Clinic Proceedings, 2003, Volume 78, Number 8, Page 965
[7]
H.A.W Neil and R.R Huxley
Atherosclerosis Supplements, 2002, Volume 3, Number 3, Page 11
[8]
Christel Jublanc, Philippe Giral, and Gérard Turpin
La Presse Médicale, 2006, Volume 35, Number 3, Page 487
[9]
Martijn B. Katan, Scott M. Grundy, Peter Jones, Malcolm Law, Tatu Miettinen, and Rodolfo Paoletti
Mayo Clinic Proceedings, 2003, Volume 78, Number 8, Page 965
[10]
Tiejie Wang, Roy C.Y. Choi, Jun Li, Cathy W.C. Bi, Wei Ran, Xiaohui Chen, Tina T.X. Dong, Kaishun Bi, and Karl W.K. Tsim
Journal of Ethnopharmacology, 2012, Volume 139, Number 1, Page 214
[11]
T. Bacchetti, S. Masciangelo, V. Bicchiega, E. Bertoli, and Gianna Ferretti
Mediterranean Journal of Nutrition and Metabolism, 2011, Volume 4, Number 3, Page 165
[12]
Sheila Anne Doggrell
Complementary Therapies in Medicine, 2011, Volume 19, Number 1, Page 37
[13]
B.-W. Huang, M.-T. Chiang, H.-T. Yao, and W. Chiang
Phytomedicine, 2005, Volume 12, Number 6-7, Page 433
[14]
Gemma Brufau, Miguel Angel Canela, and Magda Rafecas
Nutrition Research, 2008, Volume 28, Number 4, Page 217
[15]
Ignacio Párraga, Jesús López-Torres, Fernando Andrés, Beatriz Navarro, José M del Campo, Mercedes García-Reyes, María P Galdón, Ángeles Lloret, Juan C Precioso, and Joseba Rabanales
BMC Complementary and Alternative Medicine, 2011, Volume 11, Number 1, Page 73
[17]
Kathy Musa-Veloso, Theresa H. Poon, Julie Ann Elliot, and Catherine Chung
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2011, Volume 85, Number 1, Page 9
[18]
Robert A. Moreau, Bruce D. Whitaker, and Kevin B. Hicks
Progress in Lipid Research, 2002, Volume 41, Number 6, Page 457
[19]
Richard E. Ostlund
Current Opinion in Gastroenterology, 2002, Volume 18, Number 2, Page 254
[20]
Christopher P. F. Marinangeli and Peter J. H. Jones
Annals of Medicine, 2010, Volume 42, Number 5, Page 317
[21]
Wendy Jessup, Arnold Herman, and M John Chapman
Future Lipidology, 2008, Volume 3, Number 3, Page 301
[23]
[24]
Na Young Yoon, Hyeung Rak Kim, Hae Young Chung, and Jae Sue Choi
Archives of Pharmacal Research, 2008, Volume 31, Number 12, Page 1564
[25]
Eric Bruckert
Expert Opinion on Investigational Drugs, 2003, Volume 12, Number 3, Page 325

Comments (0)

Please log in or register to comment.