Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year

IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310



Diagnostic Efficiency of Cystatin C and Serum Creatinine as Markers of Reduced Glomerular Filtration Rate in the Elderly

Heinrich Burkhardt / Gero Bojarsky / Rainer Gladisch

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 11, Pages 1135–1138, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2002.199, June 2005

Publication History

Published Online:


This is a secondary analysis of data from a cross-sectional study to evaluate the diagnostic efficiency of cystatin C as a marker of the glomerular filtration rate in the elderly. Thirty patients (15 male, 15 female, mean age 75.4±7.1 years) attending a geriatric ward were enrolled. Exclusion criteria were previously diagnosed renal disease, dementia and heart failure (NYHA III or IV). Cystatin C in serum was determined by a particle-enhanced turbidimetric assay. Inulin clearance was assessed using a single-shot method. Also, Cockcroft-Gault formula was calculated. Twelve patients had a reduced glomerular filtration rate (<70 ml/min/1.73m2). The mean values were 88.4 μmol/l (±27.7) for serum creatinine, 1.57 mg/l (±0.34) for cystatin C and 88.7 ml/min/1.73 m2 (±34.6) for inulin clearance. Maximum efficiency was 0.73 for serum creatinine (cut-off limit 82 μmol/l), 0.67 for cystatin C (cut-off limit 1.63 mg/l) and 0.8 for Cockcroft and Gault estimation (cut-off limit 54 ml/min/1.73 m2). A receiver operating characteristics (ROC) analysis did not show any differences between the various methods. Therefore, cystatin C in serum may not improve the diagnostic efficiency in detecting a reduced glomerular filtration rate in the elderly. Furthermore, normal ranges for serum creatinine in the elderly might need to be adjusted.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Nicolas Maillard, Pierre Delanaye, and Christophe Mariat
Néphrologie & Thérapeutique, 2015, Volume 11, Number 1, Page 54
N. Maillard, P. Delanaye, and C. Mariat
EMC - Néphrologie, 2006, Volume 1, Number 1, Page 1
Michele Meschi, Simona Detrenis, Marcella Saccò, Marcello Bertorelli, Enrico Fiaccadori, Alberto Caiazza, and Giorgio Savazzi
Italian Journal of Medicine, 2010, Volume 4, Number 4, Page 223
G. Gueret, G. Kiss, E. Bezon, F. Lion, C. Fourmont, O. Corre, C. Vaillant, J.-L. Carre, and C.-C. Arvieux
Annales Françaises d'Anesthésie et de Réanimation, 2007, Volume 26, Number 5, Page 412
Juliana F. Roos, Jenny Doust, Susan E. Tett, and Carl M.J. Kirkpatrick
Clinical Biochemistry, 2007, Volume 40, Number 5-6, Page 383
Ariadne Avellino, Sean P. Collins, and Gregory J. Fermann
Biomarkers, 2011, Volume 16, Number 5, Page 379
Elise Wasén, Raimo Isoaho, Kari Mattila, Tero Vahlberg, Sirkka-Liisa Kivelä, and Kerttu Irjala
American Journal of Kidney Diseases, 2003, Volume 42, Number 1, Page 36
Birgit Holdt and Peter Schuff-Werner
LaboratoriumsMedizin, 2008, Volume 32, Number 2, Page -
Selda Demırtaş, Murat Can, and Ayşegül Yarpuzlu
Clinical Chemical Laboratory Medicine, 2006, Volume 44, Number 4
Magdalena Madero, Mark J Sarnak, and Lesley A Stevens
Current Opinion in Nephrology and Hypertension, 2006, Volume 15, Number 6, Page 610
Sophie Séronie-Vivien, Pierre Delanaye, Laurence Piéroni, Christophe Mariat, Marc Froissart, and Jean-Paul Cristol
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 12
Susan E Tett, Carl M J Kirkpatrick, Annette S Gross, and Andrew J McLachlan
Clinical Pharmacokinetics, 2003, Volume 42, Number 14, Page 1193

Comments (0)

Please log in or register to comment.