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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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IMPACT FACTOR 2014: 2.707
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Defining the Period of Recovery of the Glucose Concentration after Its Local Perturbation by the Implantation of a Miniature Sensor

Ting Chen / David W. Schmidtke / Adam Heller

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 8, Pages 786–789, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2002.135, June 2005

Publication History

Published Online:
2005-06-01

Abstract

At the wound caused by implanting a subcutaneous glucose sensor, the concentration of glucose differs transiently from that in the subcutaneous fluid near non-wounded skin. The period of recovery differs for different wounds and is difficult to predict. A diabetic patient implanting a subcutaneous sensor needs to know whether the transient difference subsided sufficiently for the sensor readings and the sensor's in vivo calibration to be valid. The miniature amperometric glucose sensor has a compound membrane including a layer of glucose oxidase the reaction centers of which are electrically connected to the electrode through a redox polymer; layers excluding interferents and poisons of the electrocatalytic oxidation of glucose; and a layer reducing fouling by components of the biological fluids. We show that the sensor maintains its in vitro sensitivity after its implantation for four hours in the jugular vein and in the peritoneal fluid of the rat. For a diabetic patient who implants the sensor the four-hour period is long enough for the insertion-trauma-caused local perturbation of the glucose concentration to subside and to safely rely on the readings of the implanted sensor.

Citing Articles

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[1]
George S. Wilson and Raeann Gifford
Biosensors and Bioelectronics, 2005, Volume 20, Number 12, Page 2388
[2]
Niels Lion, Frédéric Reymond, Hubert H Girault, and Joël S Rossier
Current Opinion in Biotechnology, 2004, Volume 15, Number 1, Page 31
[3]
Alessandro Ascione, Michela Flego, Silvia Zamboni, Emanuela De Cinti, Maria Luisa Dupuis, and Maurizio Cianfriglia
Hybridoma and Hybridomics, 2004, Volume 23, Number 6, Page 380
[4]
Adam Heller
AIChE Journal, 2005, Volume 51, Number 4, Page 1054

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