Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Editor-in-Chief: Plebani, Mario
Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.
IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition
SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238
Defining the Period of Recovery of the Glucose Concentration after Its Local Perturbation by the Implantation of a Miniature Sensor
Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 8, Pages 786–789, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2002.135, June 2005
- Published Online:
At the wound caused by implanting a subcutaneous glucose sensor, the concentration of glucose differs transiently from that in the subcutaneous fluid near non-wounded skin. The period of recovery differs for different wounds and is difficult to predict. A diabetic patient implanting a subcutaneous sensor needs to know whether the transient difference subsided sufficiently for the sensor readings and the sensor's in vivo calibration to be valid. The miniature amperometric glucose sensor has a compound membrane including a layer of glucose oxidase the reaction centers of which are electrically connected to the electrode through a redox polymer; layers excluding interferents and poisons of the electrocatalytic oxidation of glucose; and a layer reducing fouling by components of the biological fluids. We show that the sensor maintains its in vitro sensitivity after its implantation for four hours in the jugular vein and in the peritoneal fluid of the rat. For a diabetic patient who implants the sensor the four-hour period is long enough for the insertion-trauma-caused local perturbation of the glucose concentration to subside and to safely rely on the readings of the implanted sensor.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.