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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Glutathione Peroxidase Activity and Serum Selenium Concentration in Intrinsic Asthmatic Patients

Durdi Qujeq / Behzad Hidari / Khezroolla Bijani / Hosein Shirdel

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 2, Pages 200–202, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.032, June 2005

Publication History:
Published Online:
2005-06-01

Abstract

Serum glutathione peroxidase (GSH-Px) activity and selenium concentration were compared in intrinsic asthmatic patients and non-asthmatic control subjects. Serum GSH-Px activity and selenium concentration were assessed in 46 asthmatic patients and 75 age- and sex-matched non-asthmatic subjects by spectrophotometric assay. Mean serum GSH-Px activity was lower in intrinsic asthmatic subjects (9.4±2.6 μmol NADPH oxidized/min/g of protein) than in non-asthmatic subjects (16.3±2.9 μmol NADPH oxidized/min/g of protein). Mean serum selenium was lower in intrinsic asthmatic subjects (1.15±0.23 μM) than in non-asthmatic subjects (1.98±0.27 μM). Asthmatic patients have significantly lower concentration of selenium and GSH-Px activity measured in serum.

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