Homocysteine, Methylenetetrahydrofolate Reductase C677T Polymorphism and the B-Vitamins: A Facet of Nature-Nurture Interplay : Clinical Chemistry and Laboratory Medicine Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

30,00 € / $42.00 / £23.00

Get Access to Full Text

Homocysteine, Methylenetetrahydrofolate Reductase C677T Polymorphism and the B-Vitamins: A Facet of Nature-Nurture Interplay

Wolfgang Herrmann / Rima Obeid / Heike Schorr / Wafika Zarzour / Jürgen Geisel

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 4, Pages 547–553, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.083, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Background: Methylenetetrahydrofolate reductase 677 (MTHFR 677) polymorphism may provoke hyperhomocysteinemia when folate status is low. The influence of MTHFR 677 mutation on homocysteine (HCY) levels in relation to vitamin B12 and folate status was investigated in the current study. Subjects and methods: 113 vegetarians, 123 omnivorous Germans, and 117 omnivorous Syrians were recruited. MTHFR 677 genotype, HCY, methylmalonic acid (MMA), total serum vitamin B12, serum folate, and vitamin B6 were determined using conventional methods. Results: Omnivorous Germans displayed the lowest HCY levels compared with vegetarians and Syrians (median 8.0, 10.4, and 11.3 μmol/l, respectively). The highest serum folate and the highest MMA levels were found in vegetarians (median folate = 30.0; MMA = 355 nmol/l). Among vegetarians and Syrians, TT subjects had higher HCY levels than other genotypes which were, however, no longer significant in the highest folate tertiles. When the data were pooled, the odds ratio (OR, 95% CI) for HCY > 12 μmol/l was 3.81 (1.55–9.34) in TT compared with CC subjects. The OR increased to 28.85 (4.63–179.62) in TT subjects who had folate in the lowest tertile, and to 21.84 (4.81–99.1) in TT subjects who had MMA in the highest MMA tertile. Conclusion: MTHFR 677 TT individuals are more liable to hyperhomocysteinemia under vitamin B12 deficiency than the other two genotypes. In such a case, relative folate shortage may progressively increase HCY levels. TT individuals may have increased folate and vitamin B12 requirements compared to the other CC and CT genotypes.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Maike Wolters, Alexander Ströhle, and Andreas Hahn
Preventive Medicine, 2004, Volume 39, Number 6, Page 1256
[2]
Jürgen Geisel, Ulrich Hübner, Marion Bodis, Heike Schorr, Jean-Pierre Knapp, Rima Obeid, and Wolfgang Herrmann
Clinical Chemistry and Laboratory Medicine, 2003, Volume 41, Number 11
[3]
Betti Giusti, Anna Maria Gori, Rossella Marcucci, Claudia Saracini, Paola Bolli, and Rosanna Abbate
Aging Health, 2006, Volume 2, Number 6, Page 983
[4]
L Torres-Sánchez, J Chen, Y Díaz-Sánchez, C Palomeque, T Bottiglieri, M López-Cervantes, and L López-Carrillo
European Journal of Clinical Nutrition, 2006, Volume 60, Number 6, Page 691
[5]
Jitender Kumar, Swapan K. Das, Priyanka Sharma, Ganesan Karthikeyan, Lakshmy Ramakrishnan, and Shantanu Sengupta
Journal of Human Genetics, 2005, Volume 50, Number 12, Page 655

Comments (0)

Please log in or register to comment.