Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

30,00 € / $42.00 / £23.00

Get Access to Full Text

The Role of Interleukin-4 and Interleukin-13 in the Non-Immunologic Aspects of Asthma Pathogenesis

Kenji Izuhara

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 7, Pages 860–864, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.130, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Bronchial asthma is a complex disease characterized by airway inflammation involving a Th2-cytokine, interleukin (IL)-13. A substantial body of evidence has accumulated pointing to the pivotal role of IL-13 in the pathogenesis of bronchial asthma. The evidence is categorized as (i) analyses of mouse models, (ii) expression of these cytokines in the bronchial lesions, and (iii) genetic association of the signaling molecules of these cytokines. In addition, the molecular mechanism of the signal transduction of IL-13 has also been well characterized. We have applied microarray analyses to human bronchial epithelial cultures to search for genes regulated by IL-13 and have identified a subset of disease-relevant genes by comparison with cDNA libraries derived from normal and asthmatic bronchial biopsies. Expression of squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, was the highest in the bronchial epithelial cells stimulated by IL-4 and IL-13 and was augmented in the asthmatic cDNA library. Furthermore, serum levels of SCCA were also elevated in asthmatic patients. Taken together, it was supposed that SCCA may play some role in the pathogenesis of bronchial asthma, and measuring its serum level may be relevant for diagnosing or monitoring the status of bronchial asthma.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Annie Chamberland, Anne-Marie Madore, Karine Tremblay, Michel Laviolette, and C. Laprise
Experimental Lung Research, 2009, Volume 35, Number 5, Page 399
[2]
Tzu-Hui Li, Yi-Fen Kao, Chun-Chung Lui, and Wei-Hsi Chen
Clinical Biochemistry, 2006, Volume 39, Number 6, Page 662
[3]
Song-Chul Park, Seung Hyun Koh, Sang Heon Lee, and Jae Hoon Lee
Korean Journal of Otolaryngology-Head and Neck Surgery, 2009, Volume 52, Number 3, Page 228
[4]
Geraldine F Clough, Claire L Jackson, Jacob J P Lee, Sarah C Jamal, and Martin K Church
Journal of Investigative Dermatology, 2007
[5]
Marsha Wills- Karp
Current Allergy and Asthma Reports, 2004, Volume 4, Number 2, Page 123

Comments (0)

Please log in or register to comment.