Immunoturbidimetric Determination of C-Reactive Protein (CRP) and High-Sensitivity CRP on Heparin Plasma. Comparison with Serum Determination : Clinical Chemistry and Laboratory Medicine

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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.


IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310

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Immunoturbidimetric Determination of C-Reactive Protein (CRP) and High-Sensitivity CRP on Heparin Plasma. Comparison with Serum Determination

Anne M. Dupuy / Stéphanie Badiou / Bernard Descomps / Jean P. Cristol

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 7, Pages 948–949, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.144, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Determination of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), markers of systemic inflammation and atherosclerosis risk, usually requires serum samples, while heparin plasma samples are routinely collected for routine chemistry. This study evaluates the use of heparin plasma samples for hs-CRP and CRP determinations using immunoturbidimetric methods on an Olympus system. As a result, analytical performance, including linearity, imprecision values, and determination from 185 clinical samples, are not affected by the type of sampling, validating the use of heparin plasma samples for CRP and hs-CRP determination with Olympus reagents.

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