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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Clinical B12 Deficiency in One Case of Recurrent Spontaneous Pregnancy Loss

Mirande Candito / Sarah Magnaldo / Jacques Bayle / Jean-François Dor / Yves Gillet / André Bongain / Emmanuel Van Obberghen

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 8, Pages 1026–1027, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.157, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Moderate hyperhomocysteinaemia (HHcy) and the homozygous mutation C677T in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene are associated with increased risk of recurrent pregnancy loss. This HHcy is currently reported as a consequence of folate rather than of vitamin B12-deficient status. We describe one case of recurrent early pregnancy loss with HHcy caused by B12 deficiency. A 38-year old woman had four episodes of early spontaneous pregnancy loss. Biological data: no haemostasis disorders, HHcy (25.9 μmol/l), normal folate (5 ng/ml), B12 deficiency (<150 pg/ml) and the MTHFR C677T homozygote genotype. A bone marrow biopsy gave evidence of moderate megaloblastosis. Parenteral B12 therapy led to normal homocysteine level within 2 months and to a successful pregnancy. In conclusion, vitamin B12 deficiency is one of the causes of recurrent pregnancy loss associated with HHcy, and serum B12 should be measured systematically in this circumstance.

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