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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

13 Issues per year

IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046



Plasma Adiponectin and Hyperglycaemia in Diabetic Patients

Edoardo Mannucci / Agostino Ognibene / Francesco Cremasco / Ilaria Dicembrini / Gianluca Bardini / Marco Brogi / Alessandro Terreni / Anna Caldini / Gianni Messeri / Carlo M. Rotella

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 9, Pages 1131–1135, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.175, June 2005

Publication History

Published Online:


The insulin-sensitising adipose hormone adiponectin is reduced in type 2 diabetic patients. We assessed the relationships between plasma adiponectin and chronic hyperglycaemia. Adiponectin levels and glycated haemoglobin (HbA1c) were measured at enrolment and after 90 days in 16 patients with type 2 diabetes aged (mean ± SEM) 63.0±0.6 years, with body mass index (BMI) 30.2±0.5 kg/m2 and HbA1c concentration 7.4± 0.1%, who did not modify their hypoglycaemic treatment during the observation period. Furthermore, plasma adiponectin was measured in 29 adult patients with type 1 diabetes and compared with 29 control subjects matched for sex, age, BMI, waist circumference and bioimpedance-estimated fat mass. In type 2 diabetic patients at enrolment, adiponectin concentration correlated with BMI (r = −0.46; p < 0.05), but not with HbA1c. During the prospective observation, variations of adiponectin showed a significant correlation with variations of BMI (r = −0.47; p < 0.01), but not with variations of HbA1c concentration. These results were confirmed by multivariate analysis after adjustment for sex and age. Adiponectin levels in type 1 diabetic patients (380.8±13.7 ng/ml in women, 192.5±13.9 ng/ml in men) were significantly (p < 0.05) higher than in control subjects (277.6±11.0 ng/ml in women, 102.7±5.1 ng/ml in men); plasma adiponectin correlated significantly with BMI and waist circumference, but not with HbA1c. In conclusion, the reduction of plasma adiponectin levels in type 2 diabetic patients does not appear to be determined by chronic hyperglycaemia. Adiponectin levels are increased in type 1 diabetes, but this phenomenon is not attributable to differences in nutritional status or body composition.l21

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