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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

12 Issues per year


IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046

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Oxidative Stress in Diabetes

Ludovica Piconi / Lisa Quagliaro / Antonio Ceriello

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 9, Pages 1144–1149, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.177, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Increasing evidence in both experimental and clinical studies suggests that there is a close link between hyperglycemia, oxidative stress and diabetic complications. High blood glucose level determines overproduction of reactive oxygen species (ROS) by the mitochondria electron transport chain. High reactivity of ROS determines chemical changes in virtually all cellular components, leading to DNA and protein modification and lipid peroxidation. Measurement of biomarkers such 8-hydroxy-2′deoxyguanosine (8-OHdG), isoprostanes, malondialdehyde (MDA) and nitrotyrosine is a useful tool to assess the oxidative stress of the organism. Knowledge of the mechanisms of ROS damage of is the first step for development of new therapeutic molecules and for rationalizing the use of existing drugs.

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