Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year


IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310

VolumeIssuePage

Issues

Dyslipidemia in Patients with Type 2 Diabetes. Relationships between Lipids, Kidney Disease and Cardiovascular Disease

Wendy P. Battisti / Joanne Palmisano / William F. Keane

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 41, Issue 9, Pages 1174–1181, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2003.181, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Type 2 diabetes mellitus is a leading cause of morbidity and mortality. Cardiovascular disease (CVD) is the most prevalent complication and primarily accounts for the excess morbidity and mortality in diabetic patients, but microvascular complications, such as kidney disease and retinopathy, are frequent and contribute to the total disease burden.

Lipid abnormalities in patients with type 2 diabetes are a major problem and associated with the increased risk of CVD. The most common pattern of dyslipidemia in these patients consists of elevated levels of triglycerides and low levels of high-density lipoprotein cholesterol. Low-density lipoprotein levels in these patients are often similar to that of the nondiabetic population, although there may be important qualitative differences in the pattern that contribute to the increased risk of CVD.

Abnormal levels of urinary albumin occur in 30–40% of patients with type 2 diabetes and the presence of kidney disease enhances the mortality from CVD. Microalbuminuria, an early marker of diabetic nephropathy, is an independent risk factor for CVD. The increased levels of urinary albumin secretion may represent a more generalized vascular damage than renal microvascular injury alone.

This Review focuses on the significance of diabetic dyslipidemia and microalbuminuria to CVD risk as well as to kidney complications. We also discuss the role of aggressive therapy to ameliorate vascular injury in the diabetic patient and reduce or prevent the cardiovascular and renal consequences of the disease.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jasna Klen, Katja Goričar, Andrej Janež, and Vita Dolžan
Personalized Medicine, 2015, Volume 12, Number 3, Page 187
[2]
E. R. Pedersen, G. F. T. Svingen, H. Schartum-Hansen, P. M. Ueland, M. Ebbing, J. E. Nordrehaug, J. Igland, R. Seifert, R. M. Nilsen, and O. Nygard
European Heart Journal, 2013, Volume 34, Number 34, Page 2689
[3]
E.-H. Jang, Y.-M. Park, J. Hur, M.-K. Kim, S.-H. Ko, K.-H. Baek, K.-H. Song, K.-W. Lee, and H.-S. Kwon
Diabetic Medicine, 2013, Volume 30, Number 6, Page 694
[4]
R. S. Tirabassi, J. F. Flanagan, T. Wu, E. H. Kislauskis, P. J. Birckbichler, and D. L. Guberski
ILAR Journal, 2004, Volume 45, Number 3, Page 292
[5]
Korina Richmond, Sheila Williams, Jim Mann, Rachel Brown, and Alexandra Chisholm
ISRN Nutrition, 2013, Volume 2013, Page 1
[6]
Alan J. Garber
The American Journal of Medicine Supplements, 2005, Volume 118, Page 1
[7]
William F. Keane and Paulette A. Lyle
Cardiology Clinics, 2005, Volume 23, Number 3, Page 363
[8]
Chin-Hsiao Tseng
Clinical Biochemistry, 2009, Volume 42, Number 10-11, Page 1019
[9]
Maomao Zeng, Yizeng Liang, Hongdong Li, Bing Wang, and Xian Chen
Anal. Methods, 2011, Volume 3, Number 2, Page 438
[10]
Gary L. Pittenger, Anahit Mehrabyan, Kathryn Simmons, Amandarice, Charlotte Dublin, Patricia Barlow, and Aaron I. Vinik
Metabolic Syndrome and Related Disorders, 2005, Volume 3, Number 2, Page 113
[11]
[12]
Eun Jeong and Hee-Kyung Ro
Journal of Food Science and Nutrition, 2007, Volume 12, Number 3, Page 154
[13]
Xavier Tekpli, Laurence Huc, Jérôme Lacroix, Mary Rissel, Mallorie Poët, Josette Noël, Marie-Thérèse Dimanche-Boitrel, Laurent Counillon, and Dominique Lagadic-Gossmann
Journal of Cellular Physiology, 2008, Volume 216, Number 1, Page 207
[14]
R. Paul Wadwa
Reviews in Endocrine and Metabolic Disorders, 2007, Volume 7, Number 3, Page 197

Comments (0)

Please log in or register to comment.