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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


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Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency

Wolfgang Herrmann1 / Ulrich Hübner2 / Ines Koch3 / Rima Obeid4 / Ulrich Retzke5 / Jürgen Geisel6

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Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 42, Issue 10, Pages 1109–1116, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2004.228, June 2005

Publication History

Received:
April 8, 2004
Accepted:
August 20, 2004
Published Online:
2005-06-01

Abstract

Hyperhomocysteinemia is a risk factor in obstetrical complications such as pre-eclampsia, ‘hemolysis, elevated liver enzymes, low platelet’ (HELLP)-syndrome and placental insufficiency. The aim of our study was to investigate the alterations of homocysteine catabolism in these patients in relation to serum B-vitamins and renal function. Maternal fasting serum from preeclampsia (n = 24), HELLP (n = 20) and placental insufficiency (n = 25) patients at the time of diagnosis and pregnant controls (n = 34) was analyzed for homocysteine and its metabolites cystathionine and methylmalonic acid, the vitamins B6, B12 and folate, renal and additional parameters. Cystathionine, a parameter of homocysteine catabolism, was significantly increased in pre-eclampsia and HELLP compared with controls and placental insufficiency patients (mean concentrations: 343, 324, 248, 227 nmol/l; p=0.001). Homocysteine, folic acid, vitamin B6 and methylmalonic acid, however, did not differ significantly between groups. The main determinants of cystathionine are cystatin C and vitamin B6, whereas the main determinants of homocysteine are folate and uric acid. The strongest dependency of cystathionine on vitamin B6 was observed in pre-eclampsia and HELLP patients. The results suggest that the vitamin B6-dependent trans-sulfuration pathway is activated in pre-eclampsia and HELLP syndrome, probably by oxidative stress. Therefore, the demand for vitamin B6 is increased in these patients. Furthermore, renal dysfunction and low vitamin B6 levels contribute to the increase of cystathionine in pre-eclampsia and HELLP patients.

Keywords: cystathionine; hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome; homocysteine; oxidative stress; pre-eclampsia

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