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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

13 Issues per year

IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

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Genetic analysis of glutathione S-transferase A1 and T1 polymorphisms in a Japanese population

Kumi Matsuno / Takahiro Kubota / Yuji Matsukura / Hiroshi Ishikawa / Tatsuji Iga

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 42, Issue 5, Pages 560–562, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2004.095, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Novel allelic variants have been found in the glutathione S-transferase (GST) A1 and T1 genes. The former GSTA1*B allele is associated with low expression and the latter GSTT1*B allele lacks GSTT1 activity. The information on frequencies of both variants is poorly documented in the Japanese population. In this study we determined the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population using PCR-restriction fragment length polymorphism and allele-specific PCR. The frequencies of GSTA1*B, GSTT1*0 and GSTT1*B alleles in the subjects were 16.0%, 71.1% and 0%, respectively. This is the first report on the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population.

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