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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Comparison of cardiac troponin T and I in healthy men and in aortic valve replacement

Eberhard Gurr1 / Knut Leitz2

1.

2.

Corresponding author: Prof. Dr. Eberhard Gurr, Department of Clinical Chemistry, Zentralkrankenhaus Links der Weser, Senator-Wessling-Str. 1, 28277 Bremen, Germany. Phone: +49-421-8791670, Fax: +49-421-8791672, E-mail:

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 42, Issue 9, Pages 1020–1026, ISSN (Print) 1434-6621, DOI: 10.1515/2004.206, September 2004

Publication History

Received:
April 17, 2003
Accepted:
August 20, 2004

Abstract

Troponins are of outstanding importance for the diagnosis of myocardial infarction. Cardiac troponin T (cTnT) and the various cardiac troponin I (cTnI) assays differ with respect to method comparison, diagnostic sensitivity and diagnostic specificity. To understand the differences in the diagnostic behavior of troponin assays, AccuTnI and Elecsys Troponin STAT were used in a group of healthy men and in the follow-up of patients with aortic valve replacement (AVR). Within the healthy subjects AccuTnI was able to differentiate two subgroups from each other, whereas the cTnT concentrations of all subjects were below the detection limit. In AVR patients, cTnT and cTnI correlated sufficiently, if the postoperative periods were taken into consideration. There was a rapid increase in cTnI within 24 h. In contrast, a broad peak was evident for cTnT between 48 and 120 h. The results emphasize more the differences in the release of cTnI and cTnT from the cytoplasm and the thin filaments of the cardiomyocytes than the modifications of the troponins circulating in the blood.

Keywords: aortic valve replacement; method comparison; reference range; troponin I; troponin T

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