Jump to ContentJump to Main Navigation

Online

249,00 € / $374.00*

* Prices subject to change. Shipping costs will be added if applicable.
Publication Date:
January 2005
ISSN:
1437-4331
DOI:
10.1515/CCLM.2005.011

See all formats and pricing

Online
Individual Subscription Online only
Euro [D] 249.00
RRP for USA, Canada, Mexico
US$ 374.00 *
Print
Individual Subscription Online only
Euro [D] 1577.00
RRP for USA, Canada, Mexico
US$ 2365.00 *
Print + Online
Individual Subscription Online only
Euro [D] 1893.00
RRP for USA, Canada, Mexico
US$ 2838.00 *
*Prices subject to change. Shipping costs will be added if applicable.

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the International Federation of Clinical Chemistry and Laboratory Medicine and the European Federation of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Lippi, Giuseppe / Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Melichar, Bohuslav / Siest, Gérard / Whitfield, John B. / Abi Fadel, Marianne / Alvarez Menendez, Francisco V. / Azzazy, Hassan M.E. / Diamandis, Eleftherios P. / Eckardstein, Arnold / Favaloro, Emmanuel J. / Griesmacher, Andrea / Herrmann, Wolfgang / Hoffmann, Johannes J.M.L. / Hooijkaas, Herbert / Ichihara, Kiyoshi / Kaabachi, Naziha / Kim, Jeong-Ho / Korte, Wolfgang / Kroupis, Christos / Lai, Leslie Charles / Lam, Wai Kei Christopher / Marc, Janja / Miyoshi, Eiji / Özben, Tomris / Palicka, Vladimir / Panteghini, Mauro / Queralto, Jose M. / Scartezini, Marileia / Simundic, Ana-Maria / Tsongalis, Gregory J. / Wallemacq, Pierre E. / Yan, Shengkai / Young, Ian S. / Chiu, Rossa Wai Kwun / Ghosh, Debabrata / Kappelmayer, Janos / Lehmann, Sylvain / Sypniewska, Grazyna

12 Issues per year

Increased IMPACT FACTOR 2011: 2.150
Rank 10 out of 32 in category Medical Laboratory Technology in the 2011 Thomson Reuters Journal Citation Report/Science Edition

VolumeIssuePage

Issues

Ahead of print >

Volume 51 (0)

Volume 50 (2012)

Volume 49 (2011)

Volume 48 (2010)

Volume 47 (2009)

Volume 46 (2008)

Volume 45 (2007)

Volume 44 (2006)

Volume 43 (2005)

Volume 42 (2004)

Volume 41 (2003)

Volume 40 (2002)

Volume 39 (2001)

Volume 38 (2000)

Volume 37 (1999)

Volume 36 (1998)

Volume 35 (1997)

Volume 34 (1996)

Volume 33 (1995)

Volume 32 (1994)

Volume 31 (1993)

Volume 30 (1992)

Volume 29 (1991)

Volume 28 (1990)

Volume 27 (1989)

Volume 26 (1988)

Volume 25 (1987)

Volume 24 (1986)

Volume 23 (1985)

Volume 22 (1984)

Volume 21 (1983)

Volume 20 (1982)

Volume 19 (1981)

Volume 18 (1980)

Volume 17 (1979)

Volume 16 (1978)

Volume 15 (1977)

Volume 14 (1976)

Volume 13 (1975)

Volume 12 (1974)

Volume 11 (1973)

Volume 10 (1972)

Volume 9 (1971)

Volume 8 (1970)

Volume 7 (1969)

Volume 6 (1968)

Volume 5 (1967)

Volume 4 (1966)

Volume 3 (1965)

Volume 2 (1964)

Volume 1 (1963)

Most Downloaded Articles

  1. Global DNA hypomethylation in cancer: review of validated methods and clinical significance by Toraño, Estela G./ Petrus, Sandra/ Fernandez, Agustin F. and Fraga, Mario F.
  2. Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers? by Bergmann, Katarzyna and Sypniewska, Grazyna
  3. Preanalytical quality improvement: in quality we trust by Lippi, Giuseppe/ Becan-McBride, Kathleen/ Behúlová, Darina/ Bowen, Raffick A./ Church, Stephen/ Delanghe, Joris/ Grankvist, Kjell/ Kitchen, Steve/ Nybo, Mads/ Nauck, Matthias/ Nikolac, Nora/ Palicka, Vladimir/ Plebani, Mario/ Sandberg, Sverre and Simund...
  4. The theory of reference values: an unfinished symphony by Siest, Gerard/ Henny, Joseph/ Gräsbeck, Ralph/ Wilding, Peter/ Petitclerc, Claude/ Queraltó, Josep M. and Petersen, Peter Hyltoft
  5. The measurement of 25-hydroxy vitamin D – an analytical challenge by Herrmann, Markus

30,00 € / $42.00*

30,00 € / $42.00

Get Access to Full Text
(PDF, 57 KB)

Interference of dextran in biuret-type assays of serum proteins

Joris R. Delanghe1 / Nicole Hamers2 / Youri E. Taes3 / Jean-Claude Libeer4

1.

2.

3.

4.

Corresponding author: Prof. Dr. Joris Delanghe, Laboratory Clinical Chemistry 2P8, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium Phone: +32-9-2402956, Fax: +32-9-2404985,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 43, Issue 1, Pages 71–74, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2005.011, January 2005

Publication History:
Received:
July 20, 2004
Accepted:
October 22, 2004

Abstract

Dextran interference in biuret-type assays of total serum proteins was investigated in a Belgian National External Quality Assurance Survey with 256 participants. In vitro supplementation of therapeutic (10% Gentran 70 ®) dextran concentrations showed a broadly varying (from 0 to 20%) negative interference. The analytical interference was found to depend on both the sodium hydroxide and tartrate concentrations in the reagent formulation. The dry chemistry biuret method was not affected by the dextran interference. In a number of cases, the effects observed may be of clinical importance. Both clinicians and laboratory staff should be aware of the persistence of this analytical problem.

Keywords: biuret; dextran interference; plasma expanders; total protein assay

Comments (0)

Please log in or register to comment.