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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

12 Issues per year

IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

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Inter-individual variation of inflammatory markers of cardiovascular risks and diseases

Hind Berrahmoune1 / John Lamont2 / Peter Fitzgerald3 / Sophie Visvikis-Siest4

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Corresponding author: Dr. Sophie Visvikis-Siest, Faculté de Pharmacie, 30 rue Lionnois, 54000 Nancy, France Phone: +33-83682184, Fax: +33-83321322,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 43, Issue 7, Pages 671–684, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2005.116, August 2005

Publication History

Received:
February 22, 2005
Accepted:
May 17, 2005
Published Online:
2005-08-22

Abstract

Cardiovascular diseases are a real public health problem and have multifactorial origin. Full comprehension of these diseases is very difficult because of their clinical and biological heterogeneity. The best way to understand the development of these diseases is to first investigate each biological system involved in the diseases and secondly, interactions between them. Studying intermediate phenotype variation for these biological systems is a new and promising approach for their elucidation. Among these metabolic systems, inflammation is known to be implicated in the occurrence and worsening of cardiovascular diseases. For this review, we chose to report the most important results concerning environmental, genetic and epigenetic determinants that influence intermediate phenotypes (protein and RNA levels) of inflammation. Indeed, numerous studies have investigated these determinants in healthy populations, in other words, without the influence of either disease or medication. This new approach will help to better understand the regulation of these intermediate phenotypes and to identify a panel of risk markers, which may be useful in predicting and warning those at risk and in giving adequate treatment to each patient.

Keywords: atherosclerosis; environmental factors; intermediate phenotypes of inflammation; polymorphisms

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