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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Multicentre physiological reference values for some urinary component-to-creatinine (creatininium) concentration ratios

Xavier Fuentes-Arderiu1 / Roser Mas-Serra2 / Carmen de-Nó-Lengaran3 / Francisco Espejo-López4 / Paula Filgueiras-Martínez5 / Paula Gassiot-Cordomí6 / Isabel Idoate-Cervantes7 / María Victoria Poncela-García8 / Juan Porras-Gracia9 / Irene Sanz-Lobo10 / María del Mar Viloria-Peñas11 / Santiago Juvé-Cuxart12













Corresponding author: Xavier Fuentes-Arderiu, Laboratori Clínic, IDIBELL – Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 l'Hospitalet de Llobregat, Catalonia, Spain Fax: +34-93-260-7546,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 43, Issue 9, Pages 958–962, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2005.164, September 2005

Publication History

May 5, 2005
July 3, 2005


Nine clinical laboratories in different regions of Spain have shared the search for reference individuals and the production of reference values for urinary component-to-creatininium concentration ratios measured in first morning urine samples using RD/Hitachi<MODULAR ANALYTICS> analysers. These urinary quantities include albumin, calcium(II), chloride, magnesium(II), phosphate, potassium ion, protein, sodium ion, urate and urea. All the logistic work was done in co-operation with the reagents' and analysers' supplier (Roche Diagnostics España, S.L., Sant Cugat del Vallès, Catalonia, Spain). From the blend of reference values obtained by each laboratory, the multicentre reference limits were estimated parametrically after mathematical transformation of original data.

Keywords: multicentre reference values; physiological reference intervals; ratio quantities; urinary components

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