Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

Diagnostic and analytical performance of a screening panel for allergy

Ileana Herzum1 / Nicole Blümer2 / Werner Kersten3 / Harald Renz4

1.

2.

3.

4.

Corresponding author: Ileana Herzum, MD, Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, 35033 Marburg, Germany Phone: +49-6421-286-5031,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 43, Issue 9, Pages 963–966, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2005.165, September 2005

Publication History

Received:
May 5, 2005
Accepted:
June 22, 2005

Abstract

Worldwide, allergic diseases are increasing in prevalence and incidence. Early assessment of the immunoglobulin E (IgE) sensitisation status has a major impact on clinical outcome and selection of therapeutic options. Recently, a number of new IgE-detecting test systems have entered the market, including screening tests allowing identification of a wide spectrum of sensitising allergens. We evaluated the analytical and diagnostic performance of the newly developed Allergy Screen test panel for atopy (Mediwiss Analytic, Moers, Germany). The evaluation was performed for four major respiratory and four major nutritional allergens in 142 patients with clinical suspicion of respiratory and/or food allergies. For all allergens, the test showed acceptable concordance to the skin-prick test and the in vitro IgE CAP system (Pharmacia, Freiburg, Germany). The analytical performance was acceptable, with CVs between 2 and 8% in the positive range and good dilution linearity (R=0.9735). Imprecision in the low IgE concentration range dramatically improved by lowering the cut-off value to 0.2 IU/mL IgE. In conclusion, the Allergy Screen panel yields reliable results in the detection of allergic sensitisation to common allergens.

Keywords: allergy; CAP classes; screening; specific IgE

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Man‑Li Chang, Can Cui, Yan‑Hong Liu, Li‑Chun Pei, and Bing Shao
Biomedical Reports, 2015
[2]
Laura Orivuori, Kirsi Mustonen, Caroline Roduit, Charlotte Braun-Fahrländer, Jean-Charles Dalphin, Jon Genuneit, Roger Lauener, Petra Pfefferle, Josef Riedler, Juliane Weber, Erika von Mutius, Juha Pekkanen, and Outi Vaarala
Pediatric Allergy and Immunology, 2014, Volume 25, Number 4, Page 329
[3]
A. M. Karvonen, A. Hyvärinen, H. Rintala, M. Korppi, M. Täubel, G. Doekes, U. Gehring, H. Renz, P. I. Pfefferle, J. Genuneit, L. Keski-Nisula, S. Remes, J. Lampi, E. von Mutius, and J. Pekkanen
Allergy, 2014, Volume 69, Number 8, Page 1092
[4]
B. I. Nwaru, S. M. Virtanen, G. Alfthan, A. M. Karvonen, J. Genuneit, R. P. Lauener, J.-C. Dalphin, A. Hyvärinen, P. Pfefferle, J. Riedler, J. Weber, C. Roduit, V. Kaulek, C. Braun-Fahrländer, E. von Mutius, and J. Pekkanen
Allergy, 2014, Volume 69, Number 1, Page 87
[5]
Anna Lluis, Martin Depner, Beatrice Gaugler, Philippe Saas, Vera Isabel Casaca, Diana Raedler, Sven Michel, Jorg Tost, Jing Liu, Jon Genuneit, Petra Pfefferle, Marjut Roponen, Juliane Weber, Charlotte Braun-Fahrländer, Josef Riedler, Roger Lauener, Dominique Angèle Vuitton, Jean-Charles Dalphin, Juha Pekkanen, Erika von Mutius, and Bianca Schaub
Journal of Allergy and Clinical Immunology, 2014, Volume 133, Number 2, Page 551
[6]
Kirsi Mustonen, Laura Orivuori, Leea Keski-Nisula, Anne Hyvärinen, Petra Ina Pfefferle, Josef Riedler, Jean-Charles Dalphin, Jon Genuneit, Roger Lauener, Caroline Roduit, Charlotte Braun-Fahrländer, Juliane Weber, Bianca Schaub, Erika von Mutius, Juha Pekkanen, and Outi Vaarala
Pediatric Allergy and Immunology, 2013, Volume 24, Number 4, Page 395
[7]
Martin Depner, Markus J. Ege, Jon Genuneit, Juha Pekkanen, Marjut Roponen, Maija-Riitta Hirvonen, Jean-Charles Dalphin, Vincent Kaulek, Susanne Krauss-Etschmann, Josef Riedler, Charlotte Braun-Fahrländer, Caroline Roduit, Roger Lauener, Petra I. Pfefferle, Juliane Weber, and Erika von Mutius
Journal of Allergy and Clinical Immunology, 2013, Volume 131, Number 3, Page 781
[8]
A. M. Karvonen, A. Hyvärinen, U. Gehring, M. Korppi, G. Doekes, J. Riedler, C. Braun-Fahrländer, S. Bitter, S. Schmid, L. Keski-Nisula, M. Roponen, V. Kaulek, J.-C. Dalphin, P. I. Pfefferle, H. Renz, G. Büchele, E. Mutius, and J. Pekkanen
Clinical & Experimental Allergy, 2012, Volume 42, Number 8, Page 1246
[9]
Lung-Wen Tai, Ko-Yuan Tseng, Shaw-Tsu Wang, Chao-Cheng Chiu, Chak Hone Kow, Ping Chang, Chichen Chen, Jiu-Yao Wang, and James R. Webster
Analytical Biochemistry, 2009, Volume 391, Number 2, Page 98
[10]
Kirsi Mustonen, Leea Keski-Nisula, Outi Vaarala, Petra Ina Pfefferle, Harald Renz, Josef Riedler, Jean-Charles Dalphin, Gisela Buechele, Roger Lauener, Charlotte Braun-Fahrländer, Erika von Mutius, and Juha Pekkanen
Pediatric Allergy and Immunology, 2012, Volume 23, Number 6, Page 522
[11]
Koichi Suzuki, Mineyoshi Hiyoshi, Hitomi Tada, Miwa Bando, Takao Ichioka, Norio Kamemura, and Hiroshi Kido
Analytica Chimica Acta, 2011, Volume 706, Number 2, Page 321
[12]
Petra Ina Pfefferle, Serdar Sel, Markus Johannes Ege, Gisela Büchele, Nicole Blümer, Susanne Krauss-Etschmann, Ileana Herzum, Christoph E. Albers, Roger P. Lauener, Marjut Roponen, Maija-Riitta Hirvonen, Dominique A. Vuitton, Josef Riedler, Bert Brunekreef, Jean-Charles Dalphin, Charlotte Braun-Fahrländer, Juha Pekkanen, Erika von Mutius, and Harald Renz
Journal of Allergy and Clinical Immunology, 2008, Volume 122, Number 4, Page 711
[13]
Markus Johannes Ege, Ileana Herzum, Gisela Büchele, Susanne Krauss-Etschmann, Roger P. Lauener, Marjut Roponen, Anne Hyvärinen, Dominique A. Vuitton, Josef Riedler, Bert Brunekreef, Jean-Charles Dalphin, Charlotte Braun-Fahrländer, Juha Pekkanen, Harald Renz, and Erika von Mutius
Journal of Allergy and Clinical Immunology, 2008, Volume 122, Number 2, Page 407
[14]
Marike Kolossa-Gehring, Kerstin Becker, André Conrad, Anja Lüdecke, Stefan Riedel, Margarete Seiwert, Christine Schulz, and Regine Szewzyk
International Journal of Hygiene and Environmental Health, 2007, Volume 210, Number 5, Page 535
[15]
Jasna Lipozenčić and Ronni Wolf
Clinics in Dermatology, 2010, Volume 28, Number 1, Page 38
[16]
M. K. Rochat, M. J. Ege, D. Plabst, J. Steinle, S. Bitter, C. Braun-Fahrländer, J-C. Dalphin, J. Riedler, M. Roponen, M-R. Hirvonen, G. Büchele, H. Renz, R. Lauener, S. Krauss-Etschmann, and E. Von Mutius
Clinical & Experimental Allergy, 2009, Volume 40, Number 5, Page 786
[17]
Tiiu Saarne, Hans Grönlund, Inger Kull, Catarina Almqvist, Magnus Wickman, and Marianne van Hage
Pediatric Allergy and Immunology, 2010, Volume 21, Number 2p1, Page 277
[18]
L. Keski-Nisula, A. Karvonen, P. I. Pfefferle, H. Renz, G. Büchele, and J. Pekkanen
Allergy, 2010
[19]
Mikko Lappalainen, Marjut Roponen, Juha Pekkanen, Kati Huttunen, and Maija-Riitta Hirvonen
Pediatric Allergy and Immunology, 2009, Volume 20, Number 8, Page 714
[20]
C.-M. Chen, S. Weidinger, N. Klopp, S. Sausenthaler, W. Bischof, O. Herbarth, M. Bauer, M. Borte, B. Schaaf, I. Lehmann, H. Behrendt, U. Krämer, D. Berdel, A. von Berg, C. P. Bauer, S. Koletzko, T. Illig, H.-E. Wichmann, and J. Heinrich
Allergy, 2009, Volume 64, Number 9, Page 1327
[21]
M. J. Ege, I. Herzum, G. Büchele, S. Krauss-Etschmann, R. P. Lauener, S. Bitter, M. Roponen, S. Remes, D. A. Vuitton, J. Riedler, B. Brunekreef, J-C. Dalphin, C. Braun-Fahrländer, J. Pekkanen, H. Renz, and E. von Mutius
Allergy, 2008, Volume 63, Number 11, Page 1505

Comments (0)

Please log in or register to comment.