Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Editor-in-Chief: Plebani, Mario
Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.
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Erythrocyte membrane acetylcholinesterase activity in subjects with MTHFR 677C→T genotype
Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 1, Pages 23–27, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.005, December 2005
- August 25, 2005
- October 18, 2005
- Published Online:
Background: Increased homocysteine (Hcy) blood levels are correlated with vascular and neurological problems.
Aim: The aim of the present study was to investigate erythrocyte membrane acetylcholinesterase (AChE) activity in subjects with the MTHFR C677T genotype in relation to Hcy.
Methods: Blood was obtained from 22 individuals with the MTHFR C677T genotype before and after folic acid supplementation and once from controls (n=30). Plasma folate, vitamin B12 and total antioxidant status (TAS) were measured with commercial kits, Hcy by a HPLC method and membrane enzyme activity spectrophotometrically.
Results: In MTHFR C677T carriers, AChE activity was significantly higher (4.20±0.12
Conclusions: Increased membrane AChE activity may be due to high Hcy levels. In vitro, phenylalanine reversed the Hcy activation of the membrane enzyme from controls and alanine protected it from Hcy action.
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