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Clinical Chemistry and Laboratory Medicine (CCLM)

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Multiplexed testing in the autoimmunity laboratory

José M. González-Buitrago1


Correspondence to: Prof. José M. González-Buitrago, Servicio de Bioquímica, Hospital Universitario de Salamanca, Salamanca, Spain Fax: +34-923-291211,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 10, Pages 1169–1174, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.213, October 2006

Publication History

May 31, 2006
June 21, 2006
Published Online:


A variety of technologies for autoantibody profiling have been developed. The main techniques are line-blot immunoassays, bar-coded nanoparticle immunoassays, and bead-based assays with flow cytometry detection and antigen microarrays. Some of these technologies are only able to measure a limited number of autoantibodies, while others can detect elevated numbers. Assays for antinuclear antibody specificities using line-blot immunoassays and bead-based assays with flow cytometry detection are already commercialised. Antigen microarrays for autoantibody measurement are only in the development phase, although in the not too distant future these assays will probably appear on the market. Multiplexed testing in the autoimmunity laboratory appears to have a promising future, since this technique permits a reduction in analytical time, with a shorter turnaround time.

Clin Chem Lab Med 2006;44:1169–74.

Keywords: antigen microarray; antinuclear antibodies; autoantibody; autoimmune diseases; multiplexed tests

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