Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year

IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310



The importance of metrological traceability on the validity of creatinine measurement as an index of renal function: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)

Mauro Panteghini1 / Gary L. Myers2 / W. Greg Miller3 / Neil Greenberg4 /





Corresponding author: Prof. Mauro Panteghini, Laboratorio Analisi Chimico-Cliniche, Ospedale Luigi Sacco, Via GB Grassi, 20157 Milano, Italy Phone: +39-02-39042806, Fax: +39-02-50319835,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 10, Pages 1287–1292, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.234, October 2006


The glomerular filtration rate (GFR) is currently considered the best overall index of kidney function. The possibility that laboratories might routinely report an estimated GFR has become practically feasible with the development of a formula, the “four-variable” Modification of Diet in Renal Disease study (MDRD) equation that uses age, sex, race, and serum creatinine parameters. However, a limitation of this equation for general implementation in healthcare is related to the use of differently calibrated creatinine measurement procedures among laboratories. The only way to achieve universal implementation of the GFR prediction equation, with the associated clinical benefits for patients, is, therefore, to promote worldwide standardization of methods to determine creatinine, together with the introduction of a revised GFR-estimating equation appropriate for use with standardized creatinine methods.

Clin Chem Lab Med 2006;44:1287–92.

Keywords: calibration; creatinine; glomerular filtration rate; kidney function tests; reference standards; traceability

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Sara Pasqualetti, Ilenia Infusino, Assunta Carnevale, Dominika Szőke, and Mauro Panteghini
Clinica Chimica Acta, 2015
Fernando J. Hermida, María J. Lorenzo, Aida Pérez, María Fernández, Olatz Sagastagoia, and Concepción Magadán
Scandinavian Journal of Clinical & Laboratory Investigation, 2014, Volume 74, Number 7, Page 629
Pierre Delanaye, Etienne Cavalier, Jean-Paul Cristol, and Joris R. Delanghe
Journal of Nephrology, 2014, Volume 27, Number 5, Page 467
Anna Carobene, Ferruccio Ceriotti, Ilenia Infusino, Erika Frusciante, and Mauro Panteghini
Clinica Chimica Acta, 2014, Volume 427, Page 100
Niklas Mattsson, Ingrid Zegers, Ulf Andreasson, Maria Bjerke, Marinus A Blankenstein, Robert Bowser, Maria C Carrillo, Johan Gobom, Theresa Heath, Rand Jenkins, Andreas Jeromin, June Kaplow, Daniel Kidd, Omar F Laterza, Andrew Lockhart, Michael P Lunn, Robert L Martone, Kevin Mills, Josef Pannee, Marianne Ratcliffe, Leslie M Shaw, Adam J Simon, Holly Soares, Charlotte E Teunissen, Marcel M Verbeek, Robert M Umek, Hugo Vanderstichele, Henrik Zetterberg, Kaj Blennow, and Erik Portelius
Biomarkers in Medicine, 2012, Volume 6, Number 4, Page 409
Mikkel Krogh-Madsen, Brendan Bender, Morten Krogh Jensen, Ove Juul Nielsen, Lena E. Friberg, and Per Hartvig Honoré
Cancer Chemotherapy and Pharmacology, 2012, Volume 69, Number 5, Page 1155
Mauro Panteghini
Clinical Chemistry and Laboratory Medicine, 2012, Volume 50, Number 7
Mauro Panteghini
Clinical Biochemistry, 2009, Volume 42, Number 4-5, Page 236
Zlata Flegar-Meštrić, Sonja Perkov, Barbara Šimonović, and Dubravka Juretić
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 2
Dirk P. Boer, Yolanda B. de Rijke, Wim C. Hop, Karlien Cransberg, and Eiske M. Dorresteijn
Pediatric Nephrology, 2010, Volume 25, Number 10, Page 2107
Claus U Niemann and Natalie J Serkova
Expert Opinion on Drug Metabolism & Toxicology, 2007, Volume 3, Number 4, Page 527
Claus U Niemann and Natalie J Serkova
Expert Opinion on Drug Metabolism & Toxicology, 2007, Volume 3, Number 4, Page 527

Comments (0)

Please log in or register to comment.