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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Comparison of triglyceride concentration with lipemic index in disorders of triglyceride and glycerol metabolism

Heide De Haene1 / Youri Taes2 / Armand Christophe3 / Joris Delanghe4

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Corresponding author: Prof. Dr. Joris Delanghe, MD, PhD, Laboratory Clinical Chemistry 2P8, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium Phone: +32-9-2405405, Fax: +32-9-2404985,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 2, Pages 220–222, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.040, February 2006

Publication History

Received:
August 2, 2005
Accepted:
November 3, 2005

Abstract

Background: In plasma, triglycerides (TG) are transported in lipoprotein particles (mainly chylomicrons, very low-density and low-density lipoprotein). Turbidimetry (bichromatically at 660 and 700 nm) allows measurement of the lipemic (L) index. We explored the use of this index, in combination with a TG assay, to detect errors due to non-fasting, to assess abnormalities in TG metabolism and to detect patients with glycerol kinase deficiency (GKD).

Methods: We collected 2441 patient samples. Normolipidemic (n=2347), type IV hyperlipidemic (n=80), postprandial samples (n=22) and serial dilutions of Intralipid with saline (n=6) were selected. One patient presenting with GKD was included, as well as two patients with type I and type V hyperlipoproteinemia, respectively.

Results: We introduced the use of the ratio between the logarithm of serum triglycerides and that of the L-index (TG/L ratio).

Conclusion: Although the proposed TG/L-index ratio cannot be regarded as an alternative for the accurate diagnosis of lipid disorders, it provides additional information about TG-containing particles.

Keywords: glycerol kinase deficiency; hyperlipoproteinemia; triglycerides; very low-density lipoprotein

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