Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year


IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310

VolumeIssuePage

Issues

Urinary cystatin C as a specific marker of tubular dysfunction

Marc Conti1 / Stéphane Moutereau2 / Mokhtar Zater3 / Karim Lallali4 / Antoine Durrbach5 / Philippe Manivet6 / Pascal Eschwège7 / Sylvain Loric8

1.

2.

3.

4.

5.

6.

7.

8.

Corresponding author: Prof. Sylvain Loric, Laboratoire de Biochimie et Génétique, CHU Henri Mondor de Créteil, 51, avenue du Maréchal de Lattre de Tassigny, 94010 Créteil cedex, France Phone: +33-1-49812847, Fax: +33-1-49812842,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 3, Pages 288–291, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.050, March 2006

Publication History

Received:
October 11, 2005
Accepted:
December 16, 2005

Abstract

Background: Cystatin C (CST3), a strong inhibitor of cysteine proteinases, is freely filtered by the kidney glomerulus and is reabsorbed by the tubules, where it is almost totally catabolized, with the remainder then eliminated in urine. In tubular diseases, it seems sensible to postulate that CST3 degradation would be reduced and consequently an increase in its urinary elimination would be observed.

Methods: We report here the development of an automatic quantitative assay to measure CST3 concentrations in urine using a Behring N-Latex Cystatin C kit on a BNII laser nephelometer. We tested its clinical relevance on several kidney disease patients.

Results: This assay is sensitive (limit of detection 0.008 mg/L) and precise (within- and between-day CVs <4%). Reference values for freshly collected urine samples range from 0.03 to 0.18 mg/L. Mean urine CST3 concentrations obtained from 52 patients with kidney tubular disease (4.31±3.85 mg/L) were significantly higher than those for 60 controls (0.096±0.044 mg/L; p<0.0001) and 47 glomerular disease patients (0.106±0.133 mg/L; p<0.0001).

Conclusion: Increased urinary CST3 concentrations allow the accurate detection of tubular dysfunction among pure and mixed nephropathies. Because of its ability to be processed on automated clinical chemistry analyzers, this assay could easily be used as an adjunct to the standard panel used to screen kidney pathologies, even in emergency situations.

Keywords: cystatin C; kidney; tubular marker; tubulopathy; urine

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Maria de Fátima Castro Mendes, João Victor Salgado, José de Ribamar Lima, Teresa Cristina Alves Ferreira, Gyl Eanes Barros Silva, and Natalino Salgado Filho
Clinical Biochemistry, 2015, Volume 48, Number 7-8, Page 546
[2]
Harald Mischak, Christian Delles, Antonia Vlahou, and Raymond Vanholder
Nature Reviews Nephrology, 2015, Volume 11, Number 4, Page 221
[3]
Vikas Garg, Manish Kumar, Himansu Sekhar Mahapatra, Anubhuti Chitkara, Adesh Kumar Gadpayle, and Venketansan Sekhar
Clinical and Experimental Nephrology, 2015
[4]
J.D. García-Martínez, S. Martinez-Subiela, A. Tvarijonaviciute, M. Caldin, and J.J. Ceron
Research in Veterinary Science, 2015, Volume 99, Page 204
[5]
Konstantinos M. Pirgakis, Konstantinos Makris, Ilias Dalainas, Andreas M. Lazaris, Chrisostomos K. Maltezos, and Christos D. Liapis
Annals of Vascular Surgery, 2014, Volume 28, Number 7, Page 1649
[6]
L. Ghys, D. Paepe, P. Smets, H. Lefebvre, J. Delanghe, and S. Daminet
Journal of Veterinary Internal Medicine, 2014, Volume 28, Number 4, Page 1152
[7]
Mamta Padhy, Smita Kaushik, M.P. Girish, Sudhesna Mohapatra, Seema Shah, and Bidhan Chandra Koner
Clinica Chimica Acta, 2014, Volume 435, Page 48
[8]
Liesbeth F. E. Ghys, Evelyne Meyer, Dominique Paepe, Joris Delanghe, and Sylvie Daminet
Veterinary Clinical Pathology, 2014, Volume 43, Number 2, Page 226
[9]
Karen Tan and Sunil K. Sethi
Translational Research, 2014, Volume 164, Number 2, Page 122
[10]
Johanna Helmersson-Karlqvist, Johan Ärnlöv, Axel C. Carlsson, Johan Härmä, and Anders Larsson
Atherosclerosis, 2014, Volume 234, Number 1, Page 108
[12]
J. De Loor, S. Daminet, P. Smets, B. Maddens, and E. Meyer
Journal of Veterinary Internal Medicine, 2013, Volume 27, Number 5, Page 998
[13]
Zohra Ghlissi, Ahmed Hakim, Hela Mnif, Fatma Makni Ayadi, Khaled Zeghal, Tarak Rebai, and Zouheir Sahnoun
Renal Failure, 2013, Volume 35, Number 8, Page 1130
[14]
Stelios Kokkoris, Chrysoula Pipili, Eirini Grapsa, Theodoros Kyprianou, and Serafim Nanas
Renal Failure, 2013, Volume 35, Number 4, Page 579
[15]
Evdoxia Tsigou, Vasiliki Psallida, Christos Demponeras, Eleni Boutzouka, and George Baltopoulos
Critical Care Research and Practice, 2013, Volume 2013, Page 1
[16]
So-Jung Sohn, Sun Young Kim, Hyung Sik Kim, Young-Jin Chun, Soon Young Han, Seung Hee Kim, and Aree Moon
Toxicology Letters, 2013, Volume 217, Number 3, Page 235
[17]
Uwe Christians, Jost Klawitter, Jelena Klawitter, Nina Brunner, and Volker Schmitz
Expert Opinion on Drug Metabolism & Toxicology, 2011, Volume 7, Number 2, Page 175
[18]
David Schnell, Stéphane Deruddre, Anatole Harrois, Julien Pottecher, Claudine Cosson, Nadir Adoui, Dan Benhamou, Eric Vicaut, Elie Azoulay, and Jacques Duranteau
Shock, 2012, Volume 38, Number 6, Page 592
[19]
Xiaochun Zhang, Bill Gibson, Ryan Mori, Devon Snow-Lisy, Yuka Yamaguchi, Steven C. Campbell, Matthew N. Simmons, and Thomas M. Daly
Clinica Chimica Acta, 2013, Volume 415, Page 88
[20]
Hong-Guang Xie, Shu-Kui Wang, Chang-Chun Cao, and Ernie Harpur
Pharmacology & Therapeutics, 2013, Volume 137, Number 1, Page 100
[21]
Feria Hikmet Noraddin, Mats Flodin, Annika Fredricsson, Azita Sohrabian, and Anders Larsson
Journal of Clinical Laboratory Analysis, 2012, Volume 26, Number 5, Page 358
[22]
[23]
P. Monti, G. Benchekroun, D. Berlato, and J. Archer
Journal of Small Animal Practice, 2012, Volume 53, Number 5, Page 254
[24]
Yanhong Li, Chenlu Fu, Xiaofei Zhou, Zhihui Xiao, Xueming Zhu, Meifang Jin, Xiaozhong Li, and Xing Feng
Pediatric Nephrology, 2012, Volume 27, Number 5, Page 851
[25]
Tobias Christian Fuchs and Philip Hewitt
Biomarkers in Medicine, 2011, Volume 5, Number 6, Page 763
[26]
Azita Sohrabian, Feria Hikmet Noraddin, Mats Flodin, Annika Fredricsson, and Anders Larsson
Clinical Biochemistry, 2012, Volume 45, Number 4-5, Page 339
[27]
Tobias Christian Fuchs and Philip Hewitt
The AAPS Journal, 2011, Volume 13, Number 4, Page 615
[28]
Stefan Herget-Rosenthal, Joanna A.E. van Wijk, Martina Bröcker-Preuss, and Arend Bökenkamp
Clinical Biochemistry, 2007, Volume 40, Number 13-14, Page 946
[29]
Bart Cortjens, Annick A.N.M. Royakkers, Rogier M. Determann, Jeroen D.E. van Suijlen, Stephan S. Kamphuis, Jannetje Foppen, Anita de Boer, Cathrien.W. Wieland, Peter E. Spronk, Marcus J. Schultz, and Catherine S.C. Bouman
Journal of Critical Care, 2012, Volume 27, Number 3, Page 261
[30]
Jeffrey C. Sirota, Jelena Klawitter, and Charles L. Edelstein
Journal of Toxicology, 2011, Volume 2011, Page 1
[31]
Lesley A. Inker and Aghogho Okparavero
Current Opinion in Nephrology and Hypertension, 2011, Volume 20, Number 6, Page 631
[32]
Michael A. Ferguson, Vishal S. Vaidya, and Joseph V. Bonventre
Toxicology, 2008, Volume 245, Number 3, Page 182
[33]
Vishal S. Vaidya, Michael A. Ferguson, and Joseph V. Bonventre
Annual Review of Pharmacology and Toxicology, 2008, Volume 48, Number 1, Page 463
[34]
Marc Conti, Stéphane Moutereau, Liliane Esmilaire, Cédric Desbene, Karim Lallali, Michel Devanlay, Antoine Durrbach, Philippe Manivet, Pascal Eschwège, and Sylvain Loric
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 12
[35]
Mitchell H Rosner
Biomarkers in Medicine, 2008, Volume 2, Number 1, Page 55
[36]
Annick A. N. M. Royakkers, Johanna C. Korevaar, Jeroen D. E. van Suijlen, Lieuwe S. Hofstra, Michael A. Kuiper, Peter E. Spronk, Marcus J. Schultz, and Catherine S. C. Bouman
Intensive Care Medicine, 2011, Volume 37, Number 3, Page 493
[37]
Frank Dieterle, Elias Perentes, André Cordier, Daniel R Roth, Pablo Verdes, Olivier Grenet, Serafino Pantano, Pierre Moulin, Daniel Wahl, Andreas Mahl, Peter End, Frank Staedtler, François Legay, Kevin Carl, David Laurie, Salah-Dine Chibout, Jacky Vonderscher, and Gérard Maurer
Nature Biotechnology, 2010, Volume 28, Number 5, Page 463
[38]
Qing-Run Li, Ke-Xin Fan, Rong-Xia Li, Jie Dai, Chao-Chao Wu, Shi-Lin Zhao, Jia-Rui Wu, Chia-Hui Shieh, and Rong Zeng
Rapid Communications in Mass Spectrometry, 2010, Volume 24, Number 6, Page 823
[39]
Shamik H Shah and Ravindra L Mehta
Current Opinion in Nephrology and Hypertension, 2006, Volume 15, Number 6, Page 561
[40]
Michael Darmon, Frédérique Schortgen, Rusel Leon, Stéphane Moutereau, Julien Mayaux, Fabiano Di Marco, Jérôme Devaquet, Christian Brun-Buisson, and Laurent Brochard
Intensive Care Medicine, 2009, Volume 35, Number 6, Page 1031
[41]
Acil Jaafar, Sophie Séronie-Vivien, Laurence Malard, Patrice Massip, Etienne Chatelut, and Ivan Tack
AIDS, 2009, Volume 23, Number 2, Page 257
[42]
Sophie Séronie-Vivien, Pierre Delanaye, Laurence Piéroni, Christophe Mariat, Marc Froissart, and Jean-Paul Cristol
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 12
[43]
Vishal S. Vaidya, Sushrut S. Waikar, Michael A. Ferguson, Fitz B. Collings, Kelsey Sunderland, Costas Gioules, Gary Bradwin, Roland Matsouaka, Rebecca A. Betensky, Gary C. Curhan, and Joseph V. Bonventre
Clinical and Translational Science, 2008, Volume 1, Number 3, Page 200
[44]
Vishal S Vaidya and Joseph V Bonventre
Expert Opinion on Drug Metabolism & Toxicology, 2006, Volume 2, Number 5, Page 697

Comments (0)

Please log in or register to comment.