Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Editor-in-Chief: Plebani, Mario
Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.
IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition
SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238
Molecular detection of squamous cell carcinoma antigen transcripts in peripheral blood of cancer patients
Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 5, Pages 538–541, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.104, May 2006
- January 27, 2006
- February 6, 2006
The squamous cell carcinoma antigen (SCC-Ag) has been widely applied as a serum marker in different kinds of cancer and was reported as a target gene for the detection of tumor cells in peripheral blood in cervical cancer. Nucleic acids released into the circulation are non-invasive diagnostic tools for cancer detection. The objective of this study was to determine the utility of SCC-Ag mRNA as a cancer detection marker in blood of cancer patients. For this purpose, 77 blood samples from five gastric cancer, 23 laryngeal cancer, 31 lung cancer, nine esophageal, and nine cervical cancer patients were analyzed. The SCC gene was amplified by reverse transcription-polymerase chain reaction. SCC-Ag mRNA was detected in two patients with gastric cancer, six patients with laryngeal cancer, 17 patients with lung cancer, three patients with esophageal cancer, and two patients with cervix cancer. The detection rate was highest (54.83%) in patients with lung cancer. SCC-Ag transcripts were not detectable in the control group, indicating that molecular analysis showed no false positives. Our results indicate that this approach could be useful in a considerable number of patients and could improve the lower diagnostic yield of conventional tests.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.