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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

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1437-4331
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Molecular detection of squamous cell carcinoma antigen transcripts in peripheral blood of cancer patients

Nur Buyru1 / Hatice Tigli2 / Derya Duranyildiz3 / Nejat Dalay4

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Corresponding author: Dr. Nejat Dalay, I.U. Oncology Institute, Capa, 34390 İstanbul, Turkey Fax: +90-216-3387809,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 5, Pages 538–541, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.104, May 2006

Publication History

Received:
January 27, 2006
Accepted:
February 6, 2006

Abstract

The squamous cell carcinoma antigen (SCC-Ag) has been widely applied as a serum marker in different kinds of cancer and was reported as a target gene for the detection of tumor cells in peripheral blood in cervical cancer. Nucleic acids released into the circulation are non-invasive diagnostic tools for cancer detection. The objective of this study was to determine the utility of SCC-Ag mRNA as a cancer detection marker in blood of cancer patients. For this purpose, 77 blood samples from five gastric cancer, 23 laryngeal cancer, 31 lung cancer, nine esophageal, and nine cervical cancer patients were analyzed. The SCC gene was amplified by reverse transcription-polymerase chain reaction. SCC-Ag mRNA was detected in two patients with gastric cancer, six patients with laryngeal cancer, 17 patients with lung cancer, three patients with esophageal cancer, and two patients with cervix cancer. The detection rate was highest (54.83%) in patients with lung cancer. SCC-Ag transcripts were not detectable in the control group, indicating that molecular analysis showed no false positives. Our results indicate that this approach could be useful in a considerable number of patients and could improve the lower diagnostic yield of conventional tests.

Keywords: cancer; squamous cell carcinoma (SCC)

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