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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Hypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease

Benjamin Dieplinger1 / Werner Poelz2 / Meinhard Haltmayer3 / Thomas Mueller4





Corresponding author: Thomas Mueller, Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Seilerstaette 2-4, 4020 Linz, Austria Phone: +43-732-76773621, Fax: +43-732-76773799,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 7, Pages 830–833, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.145, June 2006

Publication History

January 30, 2006
March 10, 2006
Published Online:


There is growing evidence that adiponectin, an adipocytokine with anti-inflammatory and antiathero-genic properties, is involved in the development of atherosclerosis. The aim of the present study was to examine whether serum levels of adiponectin were associated with symptomatic atherosclerotic peripheral arterial disease (PAD). Serum concentrations of adiponectin were measured in 433 patients with symptomatic PAD and 433 controls from the Linz Peripheral Arterial Disease (LIPAD) study. Cases and controls were matched for age, sex and diabetes mellitus. The median serum level of adiponectin was significantly lower in PAD patients than in control subjects (9.5 vs. 10.8 mg/L; p=0.014). After adjustment for several possible confounding variables using multivariable logistic regression, odds ratios for symptomatic PAD were 0.95 (95% CI, 0.64–1.42; p=0.080) and 0.59 (95% CI, 0.36–0.97; p=0.037) in the second and third tertiles for adiponectin serum concentrations, respectively, compared with the first tertile. Low serum levels of adiponectin were associated with the presence of symptomatic atherosclerotic PAD, independent of traditional and non-traditional risk factors, suggesting that hypoadiponectinemia may be a marker for systemic atherosclerotic disease.

Clin Chem Lab Med 2006;44:830–3.

Keywords: adiponectin; atherosclerosis; peripheral vascular disease; risk factors

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