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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Lack of association between α2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation – preliminary report

Antonis S. Manolis1 / Nikolaos Patsouras2 / Ioannis Ilias3 / John Constantakopoulos4 / Anastasia Pyriohou5 / Anastasios Lymperopoulos6 / Dionysios H. Spathas7 / Christodoulos S. Flordellis8

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Corresponding author: Christodoulos S. Flordellis, MD, Department of Pharmacology, Patras University School of Medicine, 261 10 Rio, Patras, Greece Phone: +30-2610-996250, Fax: +30-2610-994720

Citation Information: Clinical Chemical Laboratory Medicine. Volume 44, Issue 7, Pages 807–812, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2006.155, July 2006

Publication History

Received:
January 12, 2006
Accepted:
April 8, 2006

Abstract

Background: A genetic association/prospective follow-up study was conducted to investigate whether genetic variation of the α2B-adrenergic receptor gene was associated with the risk of restenosis in 96 Greek coronary artery disease patients undergoing coronary angioplasty and stent implantation.

Methods: For comparison of genotype frequency, a control group of 83 asymptomatic individuals was also studied. The end-point of the current study was the incidence of restenosis at 7 months of clinical follow-up.

Results: The majority of patients (70/96) had the insertion/insertion genotype, fewer patients (23/96) had the insertion/deletion genotype and only 3/96 had the deletion/deletion genotype; overall the frequency distribution was not different from that of the control subjects. Restenosis occurred in 15 of the 96 patients.

Conclusions: In the population studied, α2B-adrenoreceptor polymorphisms were not found to predispose patients to an increased incidence of restenosis. Nevertheless, these findings should be considered as preliminary, taking into account the small number of patients that were studied and the rarity of the deletion/deletion genotype.

Clin Chem Lab Med 2006;44:807–12.

Keywords: α2B-adrenergic receptor; coronary heart disease; polymorphisms; restenosis

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