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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Linking laboratory and medication data: new opportunities for pharmacoepidemiological research

Maarten J. ten Berg1 / Albert Huisman2 / Patricia M.L.A. van den Bemt3 / Alfred F.A.M. Schobben4 / Antoine C.G. Egberts5 / Wouter W. van Solinge6

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Corresponding author: Wouter W. van Solinge, Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, P.O. Box 80.082, 3508TB Utrecht, The Netherlands Phone: +31-30-2507604, Fax: +31-30-2505418,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 1, Pages 13–19, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2007.009, January 2007

Publication History

Received:
July 06, 2006
Accepted:
September 29, 2006
Published Online:
2007-01-24

Abstract

Transfer of automated laboratory data collected during routine clinical care from the laboratory information system into a database format that enables linkage to other administrative (e.g., patient characteristics) or clinical (e.g., medication, diagnoses, procedures) data provides a valuable tool for clinical epidemiological research. It allows the investigation of biochemical characteristics of diseases, therapeutic effects and diagnostic and/or prognostic markers for disease with easy access and at relatively low cost. To this end, the Utrecht Patient Oriented Database (UPOD), an infrastructure of relational databases comprising data on patient characteristics, laboratory test results, medication orders, hospital discharge diagnoses and medical procedures for all patients treated at the University Medical Centre Utrecht since January 2004, was established. Current research within UPOD is focused on the innovative linkage of laboratory and medication data, which, for example, makes it possible to assess the quality of pharmacotherapy in clinical practice, to investigate interference between laboratory tests and drugs, to study the risk of adverse drug reactions, and to develop diagnostic and prognostic markers or algorithms for adverse drug reactions. Although recently established, we believe that UPOD broadens the opportunities for clinical pharmacoepidemiological research and can contribute to patient care from a laboratory perspective.

Clin Chem Lab Med 2007;45:13–9.

Keywords: clinical chemistry; clinical epidemiology; laboratory medicine; pharmacoepidemiology; research database

Citing Articles

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[1]
Esther V. Uijtendaal, Jeannette E.F. Zwart-van Rijkom, Dylan W. de Lange, Arief Lalmohamed, Wouter W. van Solinge, and Toine C.G. Egberts
Critical Care, 2015, Volume 19, Number 1
[2]
C.H. van Werkhoven, J. van der Tempel, R. Jajou, S.F.T. Thijsen, R.J.A. Diepersloot, M.J.M. Bonten, D.F. Postma, and J.J. Oosterheert
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[3]
Merel Boesveld, Martijn A. Oudijk, Steven V. Koenen, Hens A.A. Brouwers, Erik Van Beek, Janine Boon, Addy Drogtrop, Robert Euser, Inge M. Evers, Cora A. Fiedeldeij, Karst Y. Heida, Anjoke J.M. Huisjes, Guido J.J.M. Muijsers, Jaap M. Schierbeek, and Anneke Kwee
American Journal of Obstetrics and Gynecology, 2015, Volume 212, Number 3, Page 348.e1
[4]
Shira H. Fischer, Jennifer Tjia, George Reed, Daniel Peterson, Jerry H. Gurwitz, and Terry S. Field
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[5]
S. De Jong, M. Neeleman, J. J. Luykx, M. J. Ten Berg, E. Strengman, H. H. Den Breeijen, L. C. Stijvers, J. E. Buizer-Voskamp, S. C. Bakker, R. S. Kahn, S. Horvath, W. W. Van Solinge, and R. A. Ophoff
Human Molecular Genetics, 2014, Volume 23, Number 10, Page 2721
[6]
Merel Boesveld, Karst Y. Heida, Martijn A. Oudijk, Hens A. A. Brouwers, Steven V. Koenen, and Anneke Kwee
Journal of Maternal-Fetal and Neonatal Medicine, 2014, Volume 27, Number 5, Page 516
[7]
M. S. M. van Mourik, A. Troelstra, W. W. van Solinge, K. G. M. Moons, and M. J. M. Bonten
Clinical Infectious Diseases, 2013, Volume 57, Number 1, Page 85
[8]
Thijs J. Giezen, Aukje K. Mantel-Teeuwisse, Maarten J. ten Berg, Sabine M. J. M. Straus, Hubert G. M. Leufkens, Wouter W. Solinge, and Toine C. G. Egberts
European Journal of Haematology, 2012, Volume 89, Number 3, Page 256
[9]
Maarten J. ten Berg, Patricia M.L.A. van den Bemt, Sumitra Shantakumar, Dimitri Bennett, Emile E. Voest, Albert Huisman, Wouter W. van Solinge, and Toine C.G. Egberts
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[10]
Liana Hakobyan, Flora M Haaijer-Ruskamp, Dick de Zeeuw, Daniela Dobre, and Petra Denig
Health and Quality of Life Outcomes, 2011, Volume 9, Number 1, Page 83
[11]
Karin J. Velthove, Hubert G.M. Leufkens, Patrick C. Souverein, René C. Schweizer, Madelon Bracke, and Wouter W. van Solinge
Pulmonary Pharmacology & Therapeutics, 2010, Volume 23, Number 2, Page 129
[12]
Esther V. Uijtendaal, Jeannette E. F. Zwart-van Rijkom, Wouter W. van Solinge, and Toine C. G. Egberts
European Journal of Clinical Pharmacology, 2011, Volume 67, Number 9, Page 933
[13]
Man Young Park, Dukyong Yoon, KiYoung Lee, Seok Yun Kang, Inwhee Park, Suk-Hyang Lee, Woojae Kim, Hye Jin Kam, Young-Ho Lee, Ju Han Kim, and Rae Woong Park
Pharmacoepidemiology and Drug Safety, 2011, Volume 20, Number 6, Page 598
[14]
Siu W. Lam, Luke P.H. Leenen, Wouter W. van Solinge, Falco Hietbrink, and Albert Huisman
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 3
[15]
Maarten J. ten Berg, Albert Huisman, Patricia M.L.A. van den Bemt, Hanneke den Breeijen, Toine C.G. Egberts, and Wouter W. van Solinge
Biomarkers, 2011, Volume 16, Number 1, Page 51
[16]
Karin J. Velthove, Wouter W. van Solinge, Jan-Willem J. Lammers, Hubert G.M. Leufkens, René C. Schweizer, and Madelon Bracke
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 5
[17]
Arjen F.J. Geerts, Fred H.P. De Koning, Peter A.G.M. De Smet, Wouter W. Van Solinge, and Toine C.G. Egberts
Drug Safety, 2009, Volume 32, Number 12, Page 1189
[18]
Jeannette E. F. Zwart-van Rijkom, Esther V. Uijtendaal, Maarten J. ten Berg, Wouter W. van Solinge, and Antoine C. G. Egberts
British Journal of Clinical Pharmacology, 2009, Volume 68, Number 2, Page 187
[19]
Monica M. Horvath, Heidi Cozart, Asif Ahmad, Matthew K. Langman, and Jeffrey Ferranti
Journal of Patient Safety, 2009, Volume 5, Number 1, Page 35
[20]
Maarten J. ten Berg, Wouter W. van Solinge, Patricia M.L.A. van den Bemt, Albert Huisman, Alfred F.A.M. Schobben, and Toine C.G. Egberts
Drug Safety, 2009, Volume 32, Number 1, Page 69
[21]
Pharmacoepidemiology and Drug Safety, 2007, Volume 16, Number 9, Page i

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