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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Atrial natriuretic peptide and related peptides

Yoshihiro J. Akashi1 / Jochen Springer2 / Mitja Lainscak3 / Stefan D. Anker4

1Division of Applied Cachexia Research, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany and Division of Cardiology, Department of internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

2Division of Applied Cachexia Research, Center for Cardiovascular Research, Charité Campus Mitte, Berlin, Germany

3Division of Applied Cachexia Research, Department of Cardiology, Charité Campus Virchow-Klinikum, Berlin, Germany and Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia

4Division of Applied Cachexia Research, Department of Cardiology, Charité Campus Virchow-Klinikum, Berlin, Germany and Department of Clinical Cardiology, National Lung and Heart Institute, Imperial College, London, UK

Corresponding author: Jochen Springer, PhD, Division of Applied Cachexia Research, Center for Cardiovascular Research, Charité Campus Mitte, Hessische Straβe 3–4, 10115 Berlin, Germany Phone: +49-30-450525023, Fax: +49-30-450525978,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 10, Pages 1259–1267, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: 10.1515/CCLM.2007.274, October 2007

Publication History

Received:
2007-01-13
Accepted:
2007-06-01
Published Online:
2007-10-10

Abstract

In recent years, biomarkers have been recognized as important tools for diagnosis, risk stratification, and therapeutic decision-making in cardiovascular diseases. Currently, the clinical potential of several natriuretic peptides is under scientific investigation. The well-known counter-regulatory hormones are atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP) and urodilatin, which play an important role in the homeostasis of body fluid volume. ANP and BNP have already been demonstrated to have diagnostic usefulness in a great number of studies, which have progressed from bench to bedside. This article summarizes existing data on ANP and related peptides in cardiovascular and other disorders, and outlines the potential clinical usefulness of these markers.

Clin Chem Lab Med 2007;45:1259–67.

Keywords: acute coronary syndrome; atrial natriuretic peptide (ANP); brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); dendroaspis natriuretic peptide (DNP); heart failure; renal failure

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