Clinical Chemistry and Laboratory Medicine (CCLM)
Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Editor-in-Chief: Plebani, Mario
Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.
IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition
SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238
Umbilical cord blood serum procalcitonin by Time-Resolved Amplified Cryptate Emission (TRACE) technology: reference values of a potential marker of vertically transmitted neonatal sepsis
1Hospital Universitario Central de Asturias, Servicio de Bioquímica, Oviedo, Spain
2Hospital Universitario Central de Asturias, Servicio de Bioquímica, Oviedo, Spain
3Hospital Universitario Central de Asturias, Servicio de Bioquímica, Oviedo, Spain
4Hospital Universitario Central de Asturias, Servicio de Bioquímica, Oviedo, Spain
5Hospital Universitario Central de Asturias, Servicio de Bioquímica, Oviedo, Spain and Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, Oviedo, Spain
Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 11, Pages 1531–1535, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: 10.1515/CCLM.2007.304, October 2007
- Published Online:
Background: Neonatal infection remains a major diagnostic problem because of non-specific clinical signs and symptoms, as well as low sensitivity and specificity of routine laboratory tests. C-reactive protein (CRP), white blood cell count, absolute neutrophil count and immature/total neutrophil ratio are the most widely used tests in the diagnosis of sepsis and provide useful information, but none of these has demonstrated to be reliable in detecting all septic infants. Procalcitonin (PCT) has been suggested as a potentially useful laboratory test performed in umbilical cord blood when perinatal bacterial sepsis is under investigation.
Methods: In this study, the reference interval for umbilical cord blood serum PCT was established for the first time by Time-Resolved Amplified Cryptate Emission (TRACE) technology.
Results: The reference interval for PCT in umbilical cord blood serum ranged from 0.04 to 0.43 μg/L in 168 non-infected newborn infants (95% CI 0.02–0.06 and 0.35–0.60 μg/L, respectively). Cord blood serum PCT correctly classified one infected patient out of 90 newborn infants at risk of vertically transmitted sepsis and identified another neonate as a potentially infected patient despite having negative blood cultures. However, cord blood CRP misclassified 21 out of the 90 patients as infected neonates.
Conclusions: Cord blood PCT measured by TRACE is a potentially more useful early marker of neonatal sepsis than cord blood CRP.
Clin Chem Lab Med 2007;45:1531–5.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.