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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas

Kiyomi Ishibashi1 / Noboru Takamura2 / Kiyoshi Aoyagi3 / Hironori Yamasaki4 / Norio Abiru5 / Mio Nakazato6 / Shimeru Kamihira7 / Takahiro Maeda8

1Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

2Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

3Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

4Health Center, Nagasaki University, Nagasaki, Japan

5Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

6Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

7Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

8Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Corresponding author: Noboru Takamura, MD, PhD, Associate Professor, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 8528523, Japan Phone: +81-95-849-7066, Fax: +81-95-849-7069,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 11, Pages 1457–1463, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: 10.1515/CCLM.2007.313, October 2007

Publication History

Received:
2007-05-02
Accepted:
2007-07-24
Published Online:
2007-10-31

Abstract

Background: Although it has been shown that high-molecular weight adiponectin is an active form, few studies have attempted to clarify the relationship between high molecular weight adiponectin and markers linked with cardiovascular diseases in the general population.

Methods: We screened 236 Japanese study participants recruited from the general population, residing in one large and four small islands. In addition to serum lipids and lipoproteins, serum total adiponectin and each multimer were measured. The genotype single-nucleotide polymorphism 276G>T was detected in real-time PCR with LightCycler® hybridization probes, using fluorescent-labeled nucleotides.

Results: Multiple linear regression analysis showed that high-molecular weight adiponectin, as well as total adiponectin, were significantly correlated with body weight, body mass index, high-density lipoprotein cholesterol and triglycerides. Total adiponectin and high-molecular weight adiponectin concentrations were not significantly different between GG and TX (GT and TT) genotypes of 276G>T polymorphism in the adiponectin gene. Interestingly, no differences were observed for participants from the large island between GG and TX genotypes with regard to both total adiponectin and high-molecular weight adiponectin, whereas significant differences were observed for those from the small islands.

Conclusions: Our results show that total adiponectin and high-molecular weight adiponectin are associated with similar factors in the general population. Furthermore, different effects of 276G>T for participants from small and large islands suggest that regional background due to geographic barriers may control the effects of 276G>T on adiponectin concentrations.

Clin Chem Lab Med 2007;45:1457–63.

Keywords: ACDC (adipocyte-, C1Q and collagen domain-containing) gene; adiponectin (Ad); high-molecular weight adiponectin (HMW-Ad); polymorphism

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