Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year


IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310

VolumeIssuePage

Issues

The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis – a systematic review

Markus Herrmann1 / Johannes Peter Schmidt2 / Natalia Umanskaya3 / Alexandra Wagner4 / Omid Taban-Shomal5 / Thomas Widmann6 / Graziana Colaianni7 / Britt Wildemann8 / Wolfgang Herrmann9

1ANZAC Research Institute, University of Sydney, Sydney NSW, Australia and Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg/Saar, Germany

2Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg/Saar, Germany

3Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg/Saar, Germany

4Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg/Saar, Germany

5Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg/Saar, Germany

6Department of Internal Medicine I, University Hospital of Saarland, Homburg/Saar, Germany

7Department of Human Anatomy and Histology, University of Bari, Bari, Italy

8Center for Musculoskeletal Surgery, Charité-Universitätsmedizin, Berlin, Germany

9Department of Clinical Chemistry and Laboratory Medicine, University Hospital of Saarland, Homburg/Saar, Germany

Corresponding author: Dr. Markus Herrmann, ANZAC Research Institute, Bone Research Program, Gate 3, Hospital Road, Concord, NSW 2139, Australia Phone: +61-2-9767-9165, Fax: +61-2-9767-9101,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 12, Pages 1621–1632, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: 10.1515/CCLM.2007.362, December 2007

Publication History

Received:
2007-07-31
Accepted:
2007-10-19

Abstract

Hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis. Recent epidemiological, clinical and experimental studies provide a growing body of data, which is reviewed in this article.

Epidemiological and (randomized) clinical trials suggest that HHCY increases fracture risk, but has minor effects on bone mineral density. Measurement of biochemical bone turnover markers indicates a shift of bone metabolism towards bone resorption. Animal studies confirm these observations showing a reduced bone quality and stimulation of bone resorption in hyperhomocysteinemic animals. Homocysteine (HCY) has been found to accumulate in bone by collagen binding. Cell culture studies demonstrate that high HCY levels stimulate osteoclasts but not osteoblasts, indicating again a shift of bone metabolism towards bone resorption. Regarding B-vitamins, only a few in vivo studies with equivocal results have been published. However, two large cell culture studies confirm the results obtained with exogenous HCY administration. In addition, HHCY seems to have adverse affects on extracellular bone matrix by disturbing collagen crosslinking.

In conclusion, existing data suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone quality by a stimulation of bone resorption and disturbance of collagen crosslinking.

Clin Chem Lab Med 2007;45:1621–32.

Keywords: bone metabolism; folate; homocysteine; osteoporosis; vitamin B6; vitamin B12

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Tomohiko Urano and Satoshi Inoue
Biochemical and Biophysical Research Communications, 2014, Volume 452, Number 2, Page 287
[3]
Tomohiko Urano, Masataka Shiraki, Mitsuru Saito, Noriko Sasaki, Yasuyoshi Ouchi, and Satoshi Inoue
Geriatrics & Gerontology International, 2014, Volume 14, Number 4, Page 942
[4]
Fiona O’Leary and Samir Samman
Nutrients, 2010, Volume 2, Number 3, Page 299
[5]
Joerg H. Holstein, Julia Schmalenbach, Markus Herrmann, Ilona Ölkü, Patric Garcia, Tina Histing, Wolfgang Herrmann, Michael D. Menger, Tim Pohlemann, and Lutz Claes
Medical Science Monitor, 2012, Volume 18, Number 12, Page BR469
[6]
Alexander Fisher, Wichat Srikusalanukul, Michael Davis, and Paul Smith
Stroke Research and Treatment, 2013, Volume 2013, Page 1
[7]
J. P. van Wijngaarden, E. L. Doets, A. Szczecińska, O. W. Souverein, M. E. Duffy, C. Dullemeijer, A. E. J. M. Cavelaars, B. Pietruszka, P. van't Veer, A. Brzozowska, R. A. M. Dhonukshe-Rutten, and C. P. G. M. de Groot
Journal of Nutrition and Metabolism, 2013, Volume 2013, Page 1
[8]
Mariangela Rondanelli, Annalisa Opizzi, Simone Perna, and Milena Anna Faliva
Endocrinología y Nutrición, 2013, Volume 60, Number 4, Page 197
[9]
A.W. Enneman, N. van der Velde, R. de Jonge, S.G. Heil, L. Stolk, A. Hofman, F. Rivadeneira, M.C. Zillikens, A.G. Uitterlinden, and J.B.J. van Meurs
Bone, 2012, Volume 50, Number 6, Page 1401
[10]
Abdellah El Maghraoui, Imad Ghozlani, Aziza Mounach, Asmaa Rezqi, Khalid Oumghar, Lahsen Achemlal, Ahmed Bezza, and Zhor Ouzzif
Journal of Clinical Densitometry, 2012, Volume 15, Number 3, Page 328
[11]
Forrest Harold Nielsen
Journal of Trace Elements in Medicine and Biology, 2009, Volume 23, Number 3, Page 204
[12]
Yang Huang, Xiaoling Zhang, Kewei Du, Fei Yang, Yu Shi, Jingang Huang, Tingting Tang, Di Chen, and Kerong Dai
Journal of Orthopaedic Research, 2012, Volume 30, Number 2, Page 304
[13]
Cathi Dennehy and Candy Tsourounis
Maturitas, 2010, Volume 66, Number 4, Page 370
[14]
Amany K. Elshorbagy, Clara Gram Gjesdal, Eha Nurk, Grethe S. Tell, Per M. Ueland, Ottar Nygård, Aage Tverdal, Stein E. Vollset, A. David Smith, and Helga Refsum
Bone, 2009, Volume 44, Number 5, Page 954
[15]
Joerg H. Holstein, Markus Herrmann, Christina Splett, Wolfgang Herrmann, Patric Garcia, Tina Histing, Moritz Klein, Karsten Kurz, Thomas Siebel, Tim Pohlemann, and Michael D. Menger
British Journal of Nutrition, 2011, Volume 106, Number 03, Page 378
[16]
Chizumi Yamada, Shimpei Fujimoto, Kaori Ikeda, Yuki Nomura, Ami Matsubara, Miwako Kanno, Kenichiro Shide, Kiyoshi Tanaka, Eri Imai, Tsutomu Fukuwatari, Katsumi Shibata, and Nobuya Inagaki
Journal of Diabetes Investigation, 2011, Volume 2, Number 3, Page 233
[18]
J.H. Holstein, M. Herrmann, J. Schmalenbach, R. Obeid, I. Ölkü, M. Klein, P. Garcia, T. Histing, T. Pohlemann, M.D. Menger, W. Herrmann, and L. Claes
Bone, 2010, Volume 47, Number 1, Page 151
[19]
Arash Hossein-nezhad, Khadijeh Mirzaei, Zhila Maghbooli, Azam Najmafshar, and Bagher Larijani
Journal of Bone and Mineral Metabolism, 2011, Volume 29, Number 2, Page 186
[20]
Bradley A. Maron and Joseph Loscalzo
Annual Review of Medicine, 2009, Volume 60, Number 1, Page 39
[21]
Joerg H. Holstein, Markus Herrmann, Christina Splett, Wolfgang Herrmann, Patric Garcia, Tina Histing, Moritz Klein, Karsten Kurz, Thomas Siebel, Tim Pohlemann, and Michael D. Menger
Clinical Chemistry and Laboratory Medicine, 2010, Volume 48, Number 6
[22]
Stergios A. Polyzos, Athanasios D. Anastasilakis, Zoe Efstathiadou, Ioannis Litsas, Marina Kita, Athanasios Panagiotou, Athanasios Papatheodorou, Georgios Arsos, Efstratios Moralidis, Georgios Barmpalios, Efthimia Zafeiriadou, Efthimia Triantafillidou, Eleni Makrigiannaki, and Evangelos Terpos
Journal of Bone and Mineral Metabolism, 2010, Volume 28, Number 3, Page 314
[23]
M. Saito, K. Marumo, S. Soshi, Y. Kida, C. Ushiku, and A. Shinohara
Osteoporosis International, 2010, Volume 21, Number 4, Page 655
[24]
P. F. Giampietro, C. McCarty, B. Mukesh, F. McKiernan, D. Wilson, A. Shuldiner, J. Liu, J. LeVasseur, L. Ivacic, T. Kitchner, and N. Ghebranious
Osteoporosis International, 2010, Volume 21, Number 3, Page 467
[25]
Caroline Bauchart-Thevret, Barbara Stoll, and Douglas G. Burrin
Nutrition Research Reviews, 2009, Volume 22, Number 02, Page 175
[26]
L. Claes, J. Schmalenbach, M. Herrmann, I. Ölkü, P. Garcia, T. Histing, R. Obeid, H. Schorr, W. Herrmann, T. Pohlemann, M. D. Menger, and J. H. Holstein
Calcified Tissue International, 2009, Volume 85, Number 1, Page 17
[27]
Bart L. T. Vaes, Carolien Lute, Henk J. Blom, Nathalie Bravenboer, Teun J. de Vries, Vincent Everts, Rosalie A. Dhonukshe-Rutten, Michael Müller, Lisette C. P. G. M. de Groot, and Wilma T. Steegenga
Calcified Tissue International, 2009, Volume 84, Number 5, Page 413
[28]
Yi-Fei Zhang and Guang Ning
Expert Opinion on Investigational Drugs, 2008, Volume 17, Number 6, Page 953

Comments (0)

Please log in or register to comment.