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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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The genetic polymorphisms of β3-adrenergic receptor (AR) Trp64Arg and β2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients

Wei Mo1 / Guang-Gan Zhang2 / Tian-Lun Yang3 / Xing-Ping Dai4 / Hui-Hua Li5 / Hui Zeng6 / Jie Liu7 / Yuan-Ming Tan8 / Hong-Hao Zhou9 / Zhao-Qian Liu10

1Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

2Department of Cardiovascular Internal Medicine, Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China

3Department of Cardiovascular Internal Medicine, Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China

4Department of Cardiovascular Internal Medicine, Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China

5Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

6Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

7Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

8Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

9Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

10Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan, P.R. China

Corresponding author: Professor Zhao-Qian Liu, Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University Xiang-Ya School of Medicine, Changsha, Hunan 410078, P.R. China Phone: +86-731-4805380, Fax: +86-731-4805380,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 4, Pages 493–498, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: 10.1515/CCLM.2007.089, April 2007

Publication History

Received:
2006-10-10
Accepted:
2007-01-09
Published Online:
2007-04-17

Abstract

Background: Genetic polymorphisms of β3-adrenergic receptor (AR) Trp64Arg and β2-AR Gln27Glu may result in significant change in the functions of these receptors. The aims of the present study were to investigate the association between Trp64Arg, Arg16Gly and Gln27Glu polymorphisms and the susceptibility to obesity and hypertension in a Chinese population.

Methods: A total of 437 Chinese subjects including 149 obese hypertensive patients, 139 non-obese essential hypertensive patients, and 149 non-obese normotensive healthy controls were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific (AS)-PCR assays were used to identify Trp64Arg, Arg16Gly, and Gln27Glu genotypes.

Results: The allele frequencies of 64Arg and 27Glu in the obese hypertensive group were 0.178 and 0.128, respectively. Both were significantly higher than in the non-obese hypertensive and the control groups (p<0.05). Further analysis showed that this association existed only in male hypertensive patients.

Conclusions: These data reveal that frequencies of β3-AR 64Arg and β2-AR 27Glu were significantly higher in our obese hypertensive patients than in the non-obese hypertensive population and healthy controls. β3-AR Trp64Arg and β2-AR Gln27Glu genetic polymorphisms are associated with obesity in Chinese male hypertensive patients.

Clin Chem Lab Med 2007;45:493–8.

Keywords: β2-adrenergic receptor; β3-adrenergic receptor; genetic polymorphism; haplotype; obesity

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