Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

12 Issues per year


IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046

VolumeIssuePage

Issues

Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study

Paula Grönroos1 / Olli T. Raitakari2 / Mika Kähönen3 / Nina Hutri-Kähönen4 / Jukka Marniemi5 / Jorma Viikari6 / Terho Lehtimäki7

1Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Tampere, Finland and Department of Clinical Chemistry, University of Turku, Turku, Finland

2Department of Clinical Physiology, University of Turku, Turku, Finland

3Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

4Department of Paediatrics, Tampere University Hospital, Tampere, Finland

5Department of Health and Functional Capacity, Population Research Laboratory, National Public Health Institute, Turku, Finland

6Department of Medicine, University of Turku, Turku, Finland

7Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Tampere, Finland

Corresponding author: Paula Grönroos, MD, PhD, Department of Clinical Chemistry, University of Turku, Kiinamyllynkatu 4-8, PO Box 52, 20521 Turku, Finland Phone: +358-400-937460, Fax: +358-2-3133924,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 5, Pages 592–598, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: 10.1515/CCLM.2007.116, May 2007

Publication History

Received:
2006-12-21
Accepted:
2007-02-11
Published Online:
2007-05-07

Abstract

Background: We examined the influence of apolipoprotein E (apoE) polymorphism on longitudinal changes in serum lipids by following the subjects participating in The Cardiovascular Risk in Young Finns Study over a 21-year period.

Methods: Serum lipids were determined in randomly selected Finnish children and adolescents in 1980 and the subjects were re-examined in 1983, 1986 and after 21 years in 2001. ApoE polymorphism was determined in 1736 participants, and serum lipid values and apoE phenotypes were available for 1233 subjects.

Results: ApoE phenotype-related differences in serum total and low-density lipoprotein (LDL)-cholesterol were maintained throughout the 21-year follow-up from childhood to adulthood, i.e., the apoE ɛ2 allele was consistently associated with lower and the ɛ4 allele with higher total and LDL-cholesterol (p<0.001 for all). In adulthood, there was also a significant apoE phenotype-related difference in high-density lipoprotein (HDL)-cholesterol (p=0.007), and the ɛ2 allele was associated with higher and the ɛ4 allele with lower apoA-I and HDL-cholesterol. In addition, apoB increased in the phenotype order E3/2<E3/3<E4 (E4/3+E4/4) (p<0.001). The LDL-lowering effect of the ɛ2 allele was greater in adulthood than in childhood, i.e., there was a significant apoE phenotype×time interaction (p=0.039) with longitudinal change in LDL-cholesterol.

Conclusions: ApoE polymorphism is associated with lipid levels at different ages and affects the longitudinal change in LDL-cholesterol from childhood to adulthood.

Clin Chem Lab Med 2007;45:592–8.

Keywords: apolipoprotein E polymorphism; cardiovascular risk factors; cholesterol; lipids; long-term follow-up

Comments (0)

Please log in or register to comment.
Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.