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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Cervical screening in the 21st century: the case for human papillomavirus testing of self-collected specimens

Brian J. Morris1 / Barbara R. Rose2

1Basic & Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW, Australia

2Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital and The University of Sydney, Sydney, NSW, Australia

Corresponding author: Prof. Brian J. Morris, Basic & Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, NSW 2006, Australia Phone: +61-2-93513688, Fax: +61-2-93512227,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 5, Pages 577–591, ISSN (Online) 14346621, ISSN (Print) 14374331, DOI: 10.1515/CCLM.2007.127, May 2007

Publication History

Received:
2006-12-15
Accepted:
2007-02-25
Published Online:
2007-05-07

Abstract

Cervical screening by Pap smear involves a high rate of false negatives, necessitating frequent testing. Because women do not like the sampling procedure, many avoid being screened. Testing for the causative high-risk human papillomavirus (HPV) types, by PCR or other technologies, on self-collected (tampon) samples permits women to be monitored non-invasively. The high negative predictive value of HPV testing means a greater interval between tests, and thus reduces costs. HPV testing lends itself to primary screening. A kit for self-collection and return to a testing laboratory, followed by practitioner notification and follow-up if required, should result in wider participation. The higher accuracy of HPV testing should lead to improved cervical cancer prevention.

Clin Chem Lab Med 2007;45:577–91.

Keywords: cervical cancer; cervical screening; human papillomavirus; hybrid capture; polymerase chain reaction; specimen self-collection; tampon

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Brian J. Morris, Alex D. Wodak, Adrian Mindel, Leslie Schrieber, Karen A. Duggan, Anthony Dilley, Robin J. Willcourt, Michael Lowy, David A. Cooper, Eugenie R. Lumbers, C. Terry Russell, and Stephen R. Leeder
Open Journal of Preventive Medicine, 2012, Volume 02, Number 01, Page 79
[2]
Brian J. Morris, Catherine A. Hankins, Aaron A. R. Tobian, John N. Krieger, and Jeffrey D. Klausner
ISRN Urology, 2014, Volume 2014, Page 1
[3]
Alexandros Daponte, Spyros Pournaras, and Athanassios Tsakris
Women's Health, 2014, Volume 10, Number 2, Page 115
[4]
Paraskevi Mantzana, Spyros Pournaras, Chara Skentou, Efthimios Deligeoroglou, Antonios Katsioulis, George Antonakopoulos, Christos Hadjichristodoulou, Athanassios Tsakris, Ioannis E Messinis, and Alexandros Daponte
Future Virology, 2014, Volume 9, Number 4, Page 385
[5]
Lotten Darlin, Christer Borgfeldt, Ola Forslund, Emir Hénic, Joakim Dillner, and Päivi Kannisto
Journal of Clinical Virology, 2013, Volume 56, Number 1, Page 52
[6]
Marc F.D. Baay, Katrien Francois, Filip Lardon, Paul Van Royen, Patrick Pauwels, Jan B. Vermorken, Marc Peeters, and Veronique Verhoeven
Cancer Epidemiology, 2011, Volume 35, Number 1, Page 101
[7]
Marie-Cécile Vacher-Lavenu
Annales de Pathologie, 2010, Volume 30, Number 5, Page 28
[8]
Christos Kroupis and Nikolaos Vourlidis
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 11
[9]
Mariela R. Pow-Sang, Ubirajara Ferreira, Julio M. Pow-Sang, Aguinaldo C. Nardi, and Victor Destefano
Urology, 2010, Volume 76, Number 2, Page S2
[10]
Brian J. Morris, Ronald H. Gray, Xavier Castellsague, F. Xavier Bosch, Daniel T. Halperin, Jake H. Waskett, and Catherine A. Hankins
Advances in Urology, 2011, Volume 2011, Page 1
[11]
Channa E. Schmeink, Ruud L. M. Bekkers, Leon F. A. G. Massuger, and Willem J. G. Melchers
Reviews in Medical Virology, 2011, Volume 21, Number 3, Page 139
[12]
M. F. D. Baay, V. Verhoeven, H. A. J. Lambrechts, G. G. O. Pattyn, F. Lardon, P. Van Royen, and J. B. Vermorken
European Journal of Clinical Microbiology & Infectious Diseases, 2009, Volume 28, Number 11, Page 1285
[13]
H.-C. Kolberg
Der Gynäkologe, 2008, Volume 41, Number 4, Page 293
[14]
Brian J. Morris
BioEssays, 2007, Volume 29, Number 11, Page 1147

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