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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study

Peteris Tretjakovs1 / Gustavs Latkovskis2 / Normunds Licis3 / Dace Juhnevica4 / Antra Jurka5 / Inga Bormane6 / Juris I. Aivars7 / Agnis Stifts8 / Valdis Pirags9

1Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia

2Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Latvian Centre of Cardiology, Pauls Stradina Clinical University Hospital, Riga, Latvia

3Latvian Biomedical Research Centre, Riga, Latvia

4Faculty of Medicine, University of Latvia, Riga, Latvia and Latvian Centre of Cardiology, Pauls Stradina Clinical University Hospital, Riga, Latvia

5Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia

6Institute of Experimental and Clinical Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia

7Faculty of Biology, University of Latvia, Riga, Latvia

8Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia

9Faculty of Medicine, University of Latvia, Riga, Latvia and Centre of Endocrinology, Pauls Stradina Clinical University Hospital, Riga, Latvia

Corresponding author: Peteris Tretjakovs, PhD, Institute of Experimental and Clinical Medicine, University of Latvia, Ojara Vaciesa Street 4, Riga 1004, Latvia Phone: +371-7069309, Fax: +371-7612038,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 9, Pages 1145–1148, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: 10.1515/CCLM.2007.260, September 2007

Publication History

Received:
2006-09-25
Accepted:
2007-04-26
Published Online:
2007-09-11

Abstract

Background: The aim of this pilot study was to evaluate the relationship between interleukin-6 promoter –174G/C (IL-6 –174G/C) polymorphism and insulin resistance (IR) in obese patients with coronary heart disease (CHD).

Methods: Twenty obese male patients with CHD were selected from a larger database of patients (n=606). IL-6 –174G/C genotype was previously analysed and only homozygotes with the CC genotype (n=10) or GG genotype (n=10) were selected. IR was measured using the homeostasis model assessment for IR (HOMA-IR) method.

Results: Differences in age, body mass index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), hypertension, IL-6, C-reactive protein and HOMA-IR were not significant between the genotypes (p>0.05), but analysis of a homogeneity-of-slopes model showed that genotype had a significant influence on HOMA-IR (p=0.037), and the interaction between genotype and HDL-C had a pronounced tendency to affect HOMA-IR (p=0.058). Using multiple regression analysis, we found that HDL-C had a significant effect on HOMA-IR (p=0.023), and TG had a tendency to affect HOMA-IR (p=0.066) only in the CC genotype.

Conclusions: Our data show that IL-6 –174G/C polymorphism may have a significant effect on IR. A comparison between the effects of various cardiovascular risk factors showed that HDL-C may have a significant effect on HOMA-IR in the CC genotype but not in the GG genotype. Further research is needed to test the preliminary results.

Clin Chem Lab Med 2007;45:1145–8.

Keywords: adiposity; coronary heart disease; genotype; high-density lipoprotein cholesterol; insulin resistance; interleukin-6

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