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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition

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The association between lipid profiles and breast cancer among Taiwanese women

Shun-Jen Chang1 / Ming-Feng Hou2 / Shih-Meng Tsai3 / Szu-Hsien Wu4 / Linda Ann Hou5 / Hsu Ma6 / Tzyy-Yuan Shann7 / Szu-Hua Wu8 / Li-Yu Tsai9

1Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

2Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

3Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

4Department of Surgery, I-Lan Hospital, I-Lan, Taiwan and Division of Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan

5Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

6Division of Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan

7Department of Surgery, I-Lan Hospital, I-Lan, Taiwan

8Faculty of Biomedical Laboratory Science, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

9Faculty of Biomedical Laboratory Science, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

Corresponding author: Professor Li-Yu Tsai, PhD, Faculty of Biomedical Laboratory Science, College of Health Sciences, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan Phone: +886-7-3121101-2350, Fax: +886-7-2370544,

Citation Information: Clinical Chemical Laboratory Medicine. Volume 45, Issue 9, Pages 1219–1223, ISSN (Online) 14374331, ISSN (Print) 14346621, DOI: 10.1515/CCLM.2007.263, September 2007

Publication History

Received:
2007-03-20
Accepted:
2007-05-21
Published Online:
2007-09-11

Abstract

Background: Breast cancer incidence increased seven-fold from 1979 to 2002, and it has become the second most common cancer in Taiwanese women. Although the relationship between high-density lipoprotein cholesterol (HDL-C) and breast cancer has been studied, no consistent association has been explicitly confirmed. The aim of this study was to demonstrate the relationship between breast cancer and lipid profiles in Taiwanese women.

Methods: A total of 150 breast cancer patients before treatment and 71 healthy controls were enrolled. Lipid profiles in fasting serum were measured after participants gave their consent.

Results: The breast cancer patients had significantly lower values for HDL-C and apolipoprotein A-I (apoA-I), lower apoA-I/apoB ratios and higher values for very-low-density lipoprotein cholesterol (VLDL-C) than controls. After logistic regression analysis, the breast cancer patients had significantly higher values for VLDL-C and lower values for apoA-I after controlling for HDL-C and the apoA-I/apoB ratio.

Conclusions: Our findings demonstrate that higher VLDL-C and lower apoA-I values were significantly associated with breast cancer, with a greater association between apoA-I values and the development of breast cancer than for HDL-C values.

Clin Chem Lab Med 2007;45:1219–23.

Keywords: apolipoprotein; breast cancer; lipid profiles; very-low-density lipoprotein cholesterol

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