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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Cystatin C: current position and future prospects

Sophie Séronie-Vivien1 / Pierre Delanaye2 / Laurence Piéroni3 / Christophe Mariat4 / Marc Froissart5 / Jean-Paul Cristol6 /

1Département de Biologie Clinique, Institut Claudius Regaud, Université Paul Sabatier, Toulouse, France

2Université de Liège, Service de Néphrologie-Dialyse, CHU Sart Tilman, Liège, Belgium

3Service de Biochimie Métabolique, Groupe Hospitalier Pitié-Salpétrière, AP-HP, Paris, France

4Service de Néphrologie, Dialyse et Transplantation Rénale, CHU de Saint-Etienne, Saint-Etienne, France

5Service de Physiologie, Hôpital Européen Georges Pompidou, AP-HP and Faculté de Médecine, Université Paris Descartes, Paris, France

6Laboratoire de Biochimie, Centre Hospitalo-Universitaire, Montpellier, France

Corresponding author: Sophie Séronie-Vivien, Département de Biologie Clinique, Institut Claudius Regaud (CRLCC Midi-Pyrénées), 20–24 rue du Pont St. Pierre, 31052, Toulouse Cedex, France Phone: +33-5-61424221, Fax: +33-5-61424631,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 46, Issue 12, Pages 1664–1686, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2008.336, December 2008

Publication History

Received:
2008-05-26
Accepted:
2008-08-18

Abstract

Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology.

Clin Chem Lab Med 2008;46:1664–86.

Keywords: cancer; cardiovascular risk; chronic renal failure; creatinine; cystatin C; glomerular filtration rate

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