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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Reference intervals for circulating angiogenic cytokines

Sun-Young Kong1 / Hye Lin Lee2 / Hyeon-Seok Eom3 / Weon-Seo Park4 / Tak Yun5 / Hyun-Ju Kim6 / Byung-Ho Nam7 / Moon-Woo Seong8 / Do-Hoon Lee9

1Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea and Department of Laboratory Medicine, Center for Clinical Services, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

2Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

3Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea and Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

4Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea and Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

5Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

6Hematologic Oncology Clinic, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

7Cancer Registration and Biostatistics Branch, Division of Cancer Prevention, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

8Department of Laboratory Medicine, Center for Clinical Services, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

9Department of Laboratory Medicine, Center for Clinical Services, Research Institute and Hospital, National Cancer Center, Ilsan-gu, Goyang-si, Gyeonggi-do, Republic of Korea

Corresponding author: Sun-Young Kong, MD, PhD, Hematologic Malignancies Branch, Division of Translational and Clinical Research II, Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 410-769, Republic of Korea Phone: +82-31-920-1735, Fax: +82-31-920-1738,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 46, Issue 4, Pages 545–550, ISSN (Online) 14374331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2008.092, February 2008

Publication History

Received:
2007-10-01
Accepted:
2007-12-01
Published Online:
2008-02-26

Abstract

Background: The levels of angiogenic cytokines are important in the definition of baseline characteristics of cancers and to predict patient prognosis; however, the reference intervals for angiogenic cytokines have received only limited attention. Herein, we obtained reference intervals for angiogenic cytokines, including vascular endothelial growth factor (VEGF), hepatocyte growth factor, basic fibroblast growth factor, interleukin-6, vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2.

Methods: We measured these materials in serum, plasma and urine of 131 controls, according to the guidelines of the Clinical and Laboratory Standards Institute. We analyzed the association between angiogenic cytokine levels and other laboratory parameters and explored whether polymorphisms in angiogenic cytokine genes affect the levels of cytokines.

Results/Conclusions: These data allowed us to construct reference intervals for angiogenic cytokines, and we also observed that concentrations of angiogenic cytokines generally do not vary with genotype or haplotype. An exception was serum VEGF concentration; this level was marginally affected by the –1154 VEGF polymorphism.

Clin Chem Lab Med 2008;46:545–50.

Keywords: angiogenic cytokine; reference interval

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