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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Association between plasma thiols and immune activation marker neopterin in stable coronary heart disease

Katharina Schroecksnadel1 / Roland B. Walter2 / Guenter Weiss3 / Michael Mark4 / Walter H. Reinhart5 / Dietmar Fuchs6

1Department of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria

2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

3Department of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria

4Department of Internal Medicine, Kantonsspital, Chur, Switzerland

5Department of Internal Medicine, Kantonsspital, Chur, Switzerland

6Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria

Corresponding author: Dr. Dietmar Fuchs, Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Fritz Pregl Strasse 3, 6020 Innsbruck, Austria Phone: +43-512-9003-70350, Fax: +43-512-9003-73330,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 46, Issue 5, Pages 648–654, ISSN (Online) 14374331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2008.121, February 2008

Publication History:
Received:
2007-10-31
Accepted:
2007-12-18
Published Online:
2008-02-26

Abstract

Background: Studies have associated elevated plasma levels of the thiols homocysteine and cysteine with an increased risk of atherosclerosis. Their relationship with systemic inflammatory parameters and sclerosis scores was investigated in this study.

Methods: Total homocysteine, total cysteine, neopterin and C-reactive protein (CRP) concentrations were measured in blood samples of 242 patients undergoing elective coronary angiography. A total of 181 patients had coronary artery disease (CAD), as defined by occlusion of >75% of at least one of the three main coronary arteries, and 61 subjects did not have relevant coronary stenoses.

Results: Total cysteine concentrations were higher in patients suffering from coronary artery sclerosis with stepwise increases relative to the extent of coronary artery sclerosis (p<0.001). In contrast, neither total homocysteine nor the inflammatory markers, CRP and neopterin, differed between patients and controls. However, total homocysteine concentrations correlated with total cysteine (r=0.468) and neopterin concentrations (r=0.290), as well as serum creatinine (r=0.226; all p<0.001), the latter indicating a dependence of total homocysteine concentrations on kidney function. Total cysteine concentrations were associated with increased neopterin levels (r=0.231, p<0.001).

Conclusions: Total cysteine concentrations were well suited to estimate the extent of coronary artery sclerosis, while in our study of stable CAD patients total homocysteine was not increased compared to controls. The association between homocysteine, cysteine and parameters of immune activation and inflammation in our study suggests that these markers of CAD may be interdependent.

Clin Chem Lab Med 2008;46:648–54.

Keywords: coronary heart disease; cysteine; gender difference; homocysteine; neopterin

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