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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Insulin-like growth factor-I and complications of prematurity: a focus on bronchopulmonary dysplasia

Ettore Capoluongo1 / Franco Ameglio2 / Cecilia Zuppi3

1Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy

2Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy

3Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy

Corresponding author: Ettore Capoluongo, PhD, Laboratory of Molecular Biology, Department of Biochemistry and Clinical Biochemistry, Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy Phone: +39-0630154250, Fax: +39-0630156706,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 46, Issue 8, Pages 1061–1066, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2008.211, June 2008

Publication History

Published Online:


At least four premature newborn complications have been reported to be associated with low serum insulin-like growth factor-I (IGF-I) levels: bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis and brain damage. Local IGF-I concentrations have only been reported for bronchopulmonary dysplasia and these findings show that lung IGF-I levels are clearly increased (epithelial lining fluid levels), emphasizing the fact that IGF-I is differently regulated in the general circulation or at local level. The present review discusses the meaning of the association between serum IGF-I amounts and development of complications in premature newborns. Finally, some methodological indications are reported regarding the IGF-I assay procedures. It is important to establish what are the possible relationships between blood levels and those of different compartments involved in the diseases.

Clin Chem Lab Med 2008;46:1061–6.

Keywords: brain damage; bronchoalveolar lavage fluid; bronchopulmonary dysplasia; insulin-like growth factor-I; necrotizing enterocolitis; prematurity; retinopathy of prematurity

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