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Publication Date:
04 02 2009
ISSN:
1437-4331
DOI:
10.1515/CCLM.2009.042

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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the International Federation of Clinical Chemistry and Laboratory Medicine and the European Federation of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Plebani, Mario

null Lippi, Giuseppe / Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Melichar, Bohuslav / Siest, Gérard / Whitfield, John B. / Abi Fadel, Marianne / Alvarez Menendez, Francisco V. / Azzazy, Hassan M.E. / Diamandis, Eleftherios P. / Eckardstein, Arnold / Favaloro, Emmanuel J. / Griesmacher, Andrea / Herrmann, Wolfgang / Hoffmann, Johannes J.M.L. / Hooijkaas, Herbert / Ichihara, Kiyoshi / Kaabachi, Naziha / Kim, Jeong-Ho / Korte, Wolfgang / Kroupis, Christos / Lai, Leslie Charles / Lam, Wai Kei Christopher / Marc, Janja / Miyoshi, Eiji / Özben, Tomris / Palicka, Vladimir / Panteghini, Mauro / Queralto, Jose M. / Scartezini, Marileia / Simundic, Ana-Maria / Tsongalis, Gregory J. / Wallemacq, Pierre E. / Yan, Shengkai / Young, Ian S. / Chiu, Rossa Wai Kwun / Ghosh, Debabrata / Kappelmayer, Janos / Lehmann, Sylvain / Sypniewska, Grazyna

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Performance of free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands

Linskens, Ingeborg H. 1 / Levitus, Marieke 2 / Frans, Anneke 3 / Schielen, Peter C.J.I. 4 / van Vugt, John M.G. 5 / Blankenstein, Marinus A. 6 / Dijstelbloem, Hilde M. 7

1 Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands

2 Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

3 Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

4 National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

5 Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands

6 Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

7 Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

Corresponding author: Prof. M.A. Blankenstein, Department of Clinical Chemistry, VU University Medical Center, PK1 BR 020, 1007 MB Amsterdam, The Netherlands Phone: +31-20-4443872, Fax: +31-20-4443895,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 2, Pages 222–226, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.042, February 2009

Publication History:

Received: 01/07/2008;
Accepted: 06/11/2008;
Published Online: 05/03/2012

Abstract

Background: The VU University Medical Center (VUmc) was the first hospital in the Netherlands to introduce the Delfia Xpress for the analysis of free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester screening program for Down syndrome. Since then, others have implemented this system. In this study, we tested the equality of measurements for free β-hCG and PAPP-A between Delfia Xpress systems and one AutoDelfia system.

Methods: A total of 40 serum samples were aliquoted and stored at –20°C. Samples were analyzed by six Delfia Xpress systems and one AutoDelfia system over a time period of 2 years.

Results: The relationships between free β-hCG and PAPP-A were excellent for the different Delfia Xpress systems (r>0.99, p<0.0001). For PAPP-A, the agreement between the main system at VUmc and five other systems was linear with slopes between 0.99 and 1.06. Similarly, agreement for free β-hCG was linear with slopes between 0.99 and 1.09. Likewise, agreement for PAPP-A and free β-hCG was excellent for the AutoDelfia vs. the main Delfia Xpress at the VUmc (r>0.99, p<0.0001). For both PAPP-A and free β-hCG, the relationships were linear with slopes of 1.08 and 1.07.

Conclusions: We demonstrate an excellent agreement for the analysis of PAPP-A and free β-hCG between Delfia Xpress systems and one AutoDelfia system.

Clin Chem Lab Med 2009;47:222–6.

Keywords: AutoDelfia; Delfia Xpress; first trimester Down syndrome screening; free β-human chorionic gonadotrophin; pregnancy associated plasma protein-A

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