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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction

Xiang Xie1 / Yi-tong Ma2 / Zhen-yan Fu3 / Yi-ning Yang4 / Xiang Ma5 / Bang-dang Chen6 / Ying-hong Wang7 / Fen Liu8

1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

2Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

3Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

4Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

5Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

6Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

7Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

8Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China

Corresponding author: Yi-tong Ma, Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, PR China Phone: +86-991-4366169, Fax: +86-991-4366169,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 3, Pages 347–352, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.078, March 2009

Publication History

Received:
2008-10-01
Accepted:
2008-12-29

Abstract

Background: Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS) are enzymes involved in prostaglandin and prostacyclin synthesis, which have been linked to cardiovascular disease risk. We hypothesized that genetic variations altering the function of these enzymes would modify the risk of myocardial infarction (MI).

Methods: In a Chinese case control study of MI patients (n=356) and healthy controls (n=350), we investigated the roles of polymorphisms in the PGIS gene (CYP8A1) and the COX-2 gene (PTGS2) using polymerase chain reaction-restriction fragment length polymorphism analysis.

Results: The CC genotype of CYP8A1 and the –765CC genotype of PTGS2 were more common in the MI patients than in the control subjects (p=0.041, p=0.012, respectively). The odds ratio (OR) estimated by the combined analysis for the CYP8A1 CC and PTGS2 –765CC genotypes [OR=5.44; 95% confidence interval (CI): 3.12–7.23] was markedly higher than that estimated separately for the CYP8A1 CC genotype (OR=1.37; 95% CI: 0.95–2.85) or the PTGS2 –765CC genotype (OR=2.92; 95% CI: 1.78–5.76) alone.

Conclusions: The CC genotype of CYP8A1 or the –765CC genotype of PTGS2 is associated with MI, respectively. Furthermore, the significantly combined effects of these two gene variants in the arachidonic acid metabolic pathway indicate that combining the effects of a modest number of genes, whose products are known to act in a pathophysiological manner, could be a useful method to explore the association of genetic polymorphisms and polygenic inheritance disease.

Clin Chem Lab Med 2009;47:347–52.

Keywords: cyclooxygenase-2; gene polymorphism; myocardial infarction; prostacyclin synthase

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