Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

Risk loci for type 2 diabetes – Quo vadis?

Rob N.M. Weijers1

1Teaching Hospital OLVG, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

Corresponding author: R.N.M. Weijers, PhD, Teaching Hospital OLVG, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, PO Box 95500, 1090 HM Amsterdam, The Netherlands

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 4, Pages 383–386, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.077, February 2009

Publication History

Received:
2008-10-21
Accepted:
2008-12-09
Published Online:
2009-02-09

Abstract

Reduced insulin sensitivity plays a role in the early pathogenesis of type 2 diabetes, and defects in insulin secretion by pancreatic β-cells are instrumental in hyperglycemic progression. There is strong evidence that genetic factors play an important role in both of these components. Several of the single nucleotide polymorphisms (SNPs) of genes associated with an increased risk of type 2 diabetes are hypothesized to influence β-cell function. The aim of the present study was to describe the function of the latter genes, to analyze the implications of the SNP positions within or near these genes, and to evaluate the suggested primary role of pancreatic β-cells in the etiology of type 2 diabetes.

Clin Chem Lab Med 2009;47:383–6.

Keywords: genome-wide association study; mitochondrion; pancreatic β-cell function; single nucleotide polymorphism; type 2 diabetes

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
J Hansen and R Iyengar
Clinical Pharmacology & Therapeutics, 2013, Volume 93, Number 1, Page 117

Comments (0)

Please log in or register to comment.