Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4331
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

30,00 € / $42.00 / £23.00

Get Access to Full Text

A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies

Jaroslav A. Hubacek1–3, , / Jan Pitha1, 2 / Vera Adamkova1, 3 / Vera Lanska1 / Rudolf Poledne1, 2

1Institute for Clinical and Experimental Medicine, Prague, Czech Republic

2Cardiovascular Research Center, Prague, Czech Republic

3South Bohemia University, Faculty of Public Health and Social Studies, Ceske Budejovice, Czech Republic

Corresponding author: Jaroslav A. Hubacek, IKEM-DEM-LMG, Videnska 1958/9, 140 21, Prague 4, Czech Republic Phone: +420-261-363367, Fax: +420-241-721666,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 4, Pages 387–390, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.109, March 2009

Publication History

Received:
2008-10-14
Accepted:
2009-01-19
Published Online:
2009-03-12

Abstract

Background: Recently, the role of the FTO (fat mass and obesity associated) gene in obesity development was described in Western European, but not in Oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO single nucleotide polymorphism (SNP) is associated with body mass index (BMI) in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, waist-to-hip ratio (WHR), and lipid parameters.

Methods: We analyzed three large population-based samples comprising the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females).

Results: FTO rs17817449 SNP was related to BMI in males (p=0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub-analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal females (p=0.035) but not in premenopausal females (follicle-stimulating hormone <40 U/L was used as marker of premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analyzed groups.

Conclusions: These results suggest that the effect of FTO SNP rs17817449 may be, in some populations at least, restricted to males and postmenopausal females.

Clin Chem Lab Med 2009;47:387–90.

Keywords: body mass index (BMI); FTO gene; lipid; menopausal status; obesity; single nucleotide polymorphism (SNP)

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
J.A. Hubacek, M. Vrablik, D. Dlouha, V. Stanek, M. Gebauerova, V. Adamkova, R. Ceska, G. Dostálová, A. Linhart, L. Vitek, and J. Pitha
Clinica Chimica Acta, 2016
[2]
L. Zlatohlavek, M. Vrablik, E. Motykova, R. Ceska, L. Vasickova, D. Dlouha, and J.A. Hubacek
Clinical Biochemistry, 2013, Volume 46, Number 4-5, Page 313
[3]
Jaroslav A. Hubacek, Dana Dlouha, Martin Bobak, Alena Jiraskova, and Libor Vitek
European Journal of Internal Medicine, 2012, Volume 23, Number 7, Page e175
[4]
JAROSLAV A. HUBACEK, VERA ADAMKOVA, DANA DLOUHA, MILAN JIRSA, JAN ŠPERL, ANKE TÖNJES, PETER KOVACS, HYNEK PIKHART, ANNE PEASEY, and MARTIN BOBAK
Addiction, 2012, Volume 107, Number 6, Page 1185
[5]
D. Dlouha, J. Pitha, V. Lanska, and J.A. Hubacek
Clinica Chimica Acta, 2012, Volume 413, Number 15-16, Page 1222
[6]
J. A. Hubacek, D. Dlouha, V. Lanska, and V. Adamkova
Nicotine & Tobacco Research, 2012, Volume 14, Number 8, Page 998
[7]
Jaroslav A. Hubacek, Vladimír Staněk, Marie Gebauerová, Alexandra Pilipčincová, Dana Dlouhá, Rudolf Poledne, Michal Aschermann, Hana Skalická, Jana Matoušková, Andreas Kruger, Martin Pěnička, Hana Hrabáková, Josef Veselka, Petr Hájek, Věra Lánská, Věra Adámková, and Jan Piťha
Clinica Chimica Acta, 2010, Volume 411, Number 15-16, Page 1069
[8]
Wei Huang, Yanlei Sun, and Jiazhong Sun
Endocrine, 2011, Volume 39, Number 1, Page 69
[9]
Robert A Scott, Mark E S Bailey, Colin N Moran, Richard H Wilson, Noriyuki Fuku, Masashi Tanaka, Athanasios Tsiokanos, Athanasios Z Jamurtas, Evangelia Grammatikaki, George Moschonis, Yannis Manios, and Yannis P Pitsiladis
European Journal of Human Genetics, 2010, Volume 18, Number 12, Page 1339

Comments (0)

Please log in or register to comment.