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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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The prevalence and risk factors for gallstone disease

Eun-Hyung Yoo1 / Soo-Youn Lee1

1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Corresponding author: Soo-Youn Lee, MD, PhD, 50 Irwon-dong, Kangnam-ku, Department of Laboratory Medicine, Samsung Medical Center, Seoul 135-710, Korea Phone: +82-2-3410-1834, Fax: +82-2-3410-2719,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 7, Pages 795–807, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.194, June 2009

Publication History

Published Online:


Gallstone disease is one of the most prevalent gastrointestinal disorders. In addition, the costs associated with the diagnosis and treatment of gallstone disease have been rapidly increasing. The etiology and pathogenesis of gallstone disease remains incompletely understood. Gallstone formation may result from a complex interaction of genetic and environmental factors. This article reviews the prevalence and risk factors associated with gallstone disease. Understanding the pathogenesis of gallstone disease could lead to the development of better therapeutic and preventive strategies for dealing with this disease.

Clin Chem Lab Med 2009;47:795–807.

Keywords: bile; cholelithiasis; gallbladder; gallstone; prevalence; risk factors

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