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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Neutrophil CD64: a diagnostic marker for infection and sepsis

Johannes J.M.L. Hoffmann1

1Abbott Diagnostics Division, Abbott GmbH & Co. KG, Wiesbaden, Germany

Corresponding author: Dr. J.J.M.L. Hoffmann, Abbott Diagnostics Division, Abbott GmbH and Co. KG, Max-Planck-Ring 2, 65205 Wiesbaden-Delkenheim, Germany Phone: + 49 6122 581445,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 8, Pages 903–916, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.224, August 2009

Publication History



Neutrophilic granulocytes express Fcγ receptor (FcγR) [cluster of differentiation 64 (CD64) antigen] only when they are activated. Neutrophil CD64, demonstrated using flow cytometry, can be used as a diagnostic marker of infection and sepsis. Neutrophil CD64 is superior to C-reactive protein and hematological determinations for detecting systemic infection or sepsis, since it combines high sensitivity (90% or more) with high specificity (90%–100%) in both adults and children. In addition, the test performs well in distinguishing infection from flares in autoimmune inflammatory diseases and has somewhat more limited utility for differentiating bacterial from viral infection. This review summarizes the available literature regarding CD64 as a marker of infection, and outlines future clinical studies for confirming the diagnostic performance of this promising marker.

Clin Chem Lab Med 2009;47:903–16.

Keywords: cluster of differentiation 64 (CD64); diagnostic tests; Fcγ receptor (FcγR); infection; neutrophils; sensitivity; sepsis; specificity

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